Menye atike ɖesiaɖe si wodona ɖe lãme na ame la wɔa dɔ ɖekae o. Ame aɖewo tsɔa gbeɖiɖia kpena ɖe eŋu le ɣeyiɣi si me woge ɖe eme; bubuwo gblɔna na wò ŋutigbalẽ kpoo be wòagbugbɔ atu eɖokui ɖo. Ƒuƒoƒo evelia ma — biostimulators — nye hatsotso siwo le dzidzim ɖe edzi kabakaba wu le atsyɔ̃ɖoɖo me la dometɔ ɖeka, si kplɔna poly-L-lactic acid (PLLA) . Ne ètɔtɔ le alesi PLLA to vovo tso 'collagen filler' alo hyaluronic-acid filler si wozãna ɖaa gbɔ la, esiae nye esi me kɔ — tsɔ kpe ɖe nusi wòfia na emetsonuwo kple afisi woakpɔe tsoe ŋu.
Nukae nye biostimulator injection?
Menye koŋ biostimulator yɔ fũ o — eʋãa ame . Le esi teƒe be wòanɔ anyi ɖe lãkusia me abe gel ene be wòana eƒe lolome nadzi ɖe edzi enumake la, biostimulator ʋãa wò ŋutɔ wò ŋutilã be wòawɔ collagen yeye le kwasiɖa kple ɣleti siwo kplɔe ɖo me. Nusi dona tso eme la tua ame ɖo vivivi eye wòdina be yeanɔ anyi eteƒe nadidi wu nusi wotsɔ yɔa nuɖuɖui tsã.
Dɔlékuiwutike eve siwo bɔ wue nye PLLA (poly-L-lactic acid) kple CaHA (calcium hydroxylapatite) . PLLA ye nye esi ame akpa gãtɔ di be yewoagblɔ ne wogblɔ be 'collagen-stimulating injection.'
PLLA nye polymer si wowɔ, si gblẽna le nugbagbewo me si wozãna le atikewɔwɔ me ƒe bla nanewoe nye sia — le suture siwo woate ŋu alɔ me ɣeyiɣi didi aɖe do ŋgɔ na atsyɔ̃ɖoɖo. Ne wodoe ɖe eme la, eƒe nu suesuesuewo ʋãa nuwo ɖɔɖɔɖo ƒe ŋuɖoɖo si dzi wokpɔna, si ƒe nyonyome mede o: numekuku si wowɔ tso PLLA ƒe dɔwɔwɔ ŋu ƒo nu tso alesi wònaa macrophages kple fibroblasts wɔa dɔe eye wònaa TGF-β dzina ɖe edzi, si ʋãa collagen ƒomevi I yeye ƒe wɔwɔme. Esi PLLA la le gbagbãm vivivi la, kolagen yeye si wògblẽ ɖi lae nye nusi nèkpɔna ŋutɔŋutɔ.
Esia tae PLLA wɔa nu wòto vovo kura tso HA filler gbɔ ɖo:
Onset is gradual , not instant — emetsonuwo dzena le kwasiɖa geɖe me esime collagen le wɔwɔm.
Wotsɔe na abe nusɔsrɔ̃ ene — zi geɖe la, wowɔa ɣeyiɣi siwo kplɔ wo nɔewo ɖo siwo dome didi kwasiɖa geɖe.
Emetsonuwo nɔa anyi didi — zi geɖe la, anɔ abe ƒe 2 ene, ɣeaɖewoɣi la, edidi wu.
Menye nusi woateŋu atrɔ o — to vovo na hyaluronic acid la, womateŋu 'alɔ' PLLA kple hyaluronidase o, eyata aɖaŋu kple dɔnɔ ƒe tiatia le vevie wu.
Nya aɖe si woŋlɔ ɖi anukwaretɔe na dɔnɔwo ƒe kakaɖedzi: togbɔ be woŋlɔ dɔdaƒe ŋuti nuteƒekpɔkpɔ kple mɔnu si wozãna la ɖi nyuie hã la, a ɖoɖowɔɖi me toto le PLLA ŋu le mo ƒe atsyɔ̃ɖoɖo me ɖee fia be dodokpɔ ƒe kpeɖodzi deŋgɔwo gale ŋgɔ yim — eyata ɖo mɔkpɔkpɔwo ƒo xlã vivivi, ame ɖekaɖekawo ƒe emetsonuwo tsɔ wu kakaɖedziwo.
PLLA vs kolagen yɔyɔ vs HA ƒoƒo
Amewo zãa 'collagen filler' le mɔ si mebɔbɔ o nu, eyata mina míama etɔ̃awo dome:
Collagen si wodona ɖe lãme na ame le blema — si woɖena tso lãwo me zi geɖe — ƒe akpa gãtɔ megadzea ame ŋu o elabena enɔa agbe kpuie eye wòhea nulɔdɔ ƒe afɔku vɛ. Egbea 'collagen' dzeɖoɖoa ku ɖe wò ŋutɔ wò collagen ʋuʋu ŋu ŋutɔŋutɔ , si nye nusi tututu PLLA wɔna.
Wo ame evea siaa ƒe nyuitɔ kekeake: HA + PLLA le ɖeka me
Mɔnu yeyetɔ kekeake ƒo xexemenunya eveawo nu ƒu. Atike si wɔa nu eve naa HA hena eƒe lolome enumake kple PLLA hena ɣeyiɣi didi ƒe collagen ƒe dzodzo — èdzena be gbɔdzɔe le ŋuwò enumake, emegbe nàyi edzi anɔ nyonyom ɖe edzi ne collagen yeyewo le dodom. AOMA ƒe Wotu PllaHAfill® PLLA + HA filler ɖe gɔmeɖose sia dzi: cross-linked HA naa ɖɔɖɔɖo enumake, esime PLLA microspheres ɖeka (siwo wowɔ kple SDAM ɖoɖo si ŋu woɖe mɔ ɖo hena nusuewo ƒe lolome si mewɔa tɔtrɔ o, si woate ŋu agblɔ ɖi) ɖea asi le eŋu vivivi le abe ɣleti 24 ene me be wòaʋu collagen ƒe wɔwɔme — si ɖea 'latency period' dɔnɔwo melɔ̃na kple PLLA dzadzɛ dzi kpɔtɔna.
Nusitae adzɔnuwo ƒe nyonyome nye nusi ŋu womate ŋu awɔ ɖoɖo ɖo kple PLLA o
Le PLLA gome la, nusuewo ƒe ɖekawɔwɔe nye nusianu. Wodo ƒome kple nusue siwo mewɔ ɖeka o alo esiwo ƒo ƒu ɖekae kple afɔku gã si le nodules kple emetsonu siwo mesɔ o me, eye esi wònye be womate ŋu atrɔ PLLA o ta la, atike si ƒe nyonyome mede o nye kuxi ŋutɔŋutɔ. Microspheres siwo mewɔa tɔtrɔ o, siwo le dzogoe ene me, siwo ƒe lolome sɔ la gbugbɔna wɔa nu nyuie eye wokakana abe alesi woate ŋu agblɔe ɖi ene — si nye adzɔnuwo wɔwɔ ƒe dzidzedzekpɔkpɔ, ke menye asitsatsa ƒe nya o.
Afi siae afisi woakpɔ nu tsoe le vevie le. AOMA ƒe PLLA filler range zãa PLLA-b-PEG microspheres siwo wowɔ na ɖekawɔwɔ, ɣeyiɣi didi ƒe kaka be wòakpe ɖe ame ŋu be woaxe mɔ ɖe dɔdzẽ kple vuvu nu, eye woxɔ CE-ɖaseɖigbalẽ eye wowɔe le atikewɔwɔ-grade wɔwɔ ƒe dzidzenuwo te — gɔmedzedze si wòle be atikewɔƒe ɖesiaɖe nabia hafi ado atike si womate ŋu atrɔ o.
Nukae nye PLLA filler? PLLA (poly-L-lactic acid) nye atike si doa ŋusẽ wò ŋutilã si ʋãa wò ŋutilã be wòawɔ eya ŋutɔ ƒe collagen le ɣeyiɣi aɖe megbe, tsɔ wu be wòatsɔ gel ƒe agbɔsɔsɔme akpe ɖe eŋu enumake abe HA si wotsɔ yɔa nu me ene.
Ðe PLLA sɔ kple kolagen si wotsɔ yɔa nu mea? Menye nenema tututue o. 'collagen fillers' xoxowo doa nunala ƒe kolagen hena ɣeyiɣi kpui aɖe ƒe lolome. PLLA doa ŋusẽ wò ŋutɔ wò kolagen hena emetsonu vivivi, si nɔa anyi didi.
Ɣeyiɣi didi kae PLLA nɔa anyi? Zi geɖe la, emetsonuwo nɔa anyi abe ƒe eve alo esi wu nenema ene, didi wu HA filler akpa gãtɔ — gake wotua wo ɖo vivivi le ɣeyiɣi aɖewo me tsɔ wu be woadze enumake.
Ðe woate ŋu aɖe PLLA ɖa ne nane gblẽa? Ao, to vovo na HA-fillers la, womate ŋu atrɔ PLLA kple hyaluronidase o, si tae atikekui si si nuteƒekpɔkpɔ le kple atike si ƒe nyonyome deŋgɔ, si sɔ le vevie ɖo.
Ðe PLLA nyo wu HA fillera? Wowɔa dɔ vovovowo — HA na gbeɖiɖi si sɔ enumake; PLLA na collagen-tutu vivivi kple agbenɔƒe didi. Egbegbe atikewɔwɔ geɖe ƒoa evea siaa nu ƒu.
