ꯑꯦꯁ꯭ꯇꯦꯇꯤꯛꯁ ꯱ꯑꯦꯝ.ꯑꯦꯜ.ꯄꯤ.ꯑꯦꯜ.ꯑꯦꯜ.ꯑꯦ.ꯑꯩꯆ.ꯑꯦ.

Pllahafill® ꯑꯁꯤ ꯈꯪꯖꯤꯅꯕꯤꯌꯨ: ꯅꯍꯥꯛꯀꯤ ꯑꯔꯣꯏꯕꯥ ꯐꯦꯁꯤꯑꯦꯜ ꯔꯤꯚꯥꯏꯇꯦꯂꯥꯏꯖꯦꯁꯟ ꯄꯥꯔꯇꯅꯔ

pllahafill® ꯑꯅꯚꯦꯂꯤꯡ ꯇꯧꯕꯥ: ꯑꯔꯣꯏꯕꯥ ꯗꯔꯃꯦꯜ ꯐꯤꯂꯔ

Pllahafill® ꯑꯁꯤ ꯐꯦꯁꯤꯑꯦꯜ ꯑꯦꯖꯤꯡꯒꯤ ꯀꯝꯞꯂꯦꯛꯁꯁꯤꯡ ꯑꯁꯤ ꯊꯦꯡꯅꯅꯕꯥ ꯌꯥꯝꯅꯥ ꯀꯨꯞꯅꯥ ꯗꯤꯖꯥꯏꯟ ꯇꯧꯕꯥ ꯁꯣꯐꯤꯁ꯭ꯇꯤꯀꯦꯠ ꯗꯔꯃꯦꯜ ꯐꯤꯂꯔ ꯑꯃꯅꯤ꯫ ꯃꯁꯤ ꯃꯌꯥꯌ ꯑꯣꯏꯕꯥ ꯑꯃꯁꯨꯡ ꯑꯀꯅꯕꯥ ꯅꯦꯁꯣꯂꯦꯕꯤꯌꯥꯜ ꯐꯜꯗꯁꯤꯡ ꯑꯃꯁꯨꯡ ꯑꯇꯩ ꯐꯦꯁꯤꯑꯦꯜ ꯔꯤꯡꯀꯦꯂꯁꯤꯡ ꯑꯁꯤ ꯏꯐꯦꯛꯇꯤꯚ ꯑꯣꯏꯅꯥ ꯊꯦꯡꯅꯅꯕꯥ ꯗꯤꯞ ꯗꯔꯃꯤꯁ ꯅꯠꯠꯔꯒꯥ ꯁꯕꯛꯌꯨꯇꯦꯅꯤꯌꯝ ꯂꯦꯌꯥꯔꯁꯤꯡꯗꯥ ꯁ꯭ꯠꯔꯥꯇꯦꯖꯤꯛ ꯑꯣꯏꯅꯥ ꯏꯅꯖꯦꯛꯇ ꯇꯧꯏ꯫ ꯂꯥꯌꯦꯡꯕꯒꯤ ꯃꯐꯃꯁꯤꯡ ꯑꯁꯤꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯃꯀꯣꯛ, ꯃꯟꯗꯤꯔꯁꯤꯡ, ꯑꯥꯏꯕ꯭ꯔꯣ ꯑꯥꯔꯆꯁꯤꯡ, ꯅꯥꯀꯣꯡꯒꯤ ꯊꯣꯡ, ꯀꯣꯂꯝ, ꯅꯥꯀꯣꯡꯒꯤ ꯕꯦꯖ, ꯆꯦꯛꯀꯤ, ꯈꯣꯡ, ꯑꯃꯁꯨꯡ ꯆꯤꯟ ꯑꯁꯤ ꯌꯥꯎꯏ ꯑꯗꯨꯕꯨ ꯃꯁꯤꯗꯥ ꯂꯤꯃꯤꯠ ꯂꯩꯇꯦ꯫

ꯐꯣꯔꯃꯨꯂꯦꯁꯟ ꯕ꯭ꯔꯤꯂꯤꯌꯟꯁ: pllahafill® ꯀꯝꯄꯣꯖꯤꯁꯟ

PLLAHAFILL® ꯑꯁꯤ ꯃꯤꯜꯀꯤ ꯍꯣꯏꯠ, ꯚꯤꯁ꯭ꯀꯣꯁ ꯖꯦꯜ ꯑꯃꯥ ꯑꯣꯏꯅꯥ ꯄꯤꯔꯤ, ꯃꯁꯤꯗꯥ 17mg/ml ꯁꯣꯗꯤꯌꯝ ꯍꯥꯏꯑꯦꯂꯨꯔꯣꯅꯦꯠ ꯌꯥꯝꯅꯥ ꯌꯥꯎꯏ ꯑꯃꯁꯨꯡ PLLA-B-PEG ꯃꯥꯏꯛꯔꯣꯁ꯭ꯐꯤꯌꯥꯔꯁꯤꯡꯒꯤ 18%ꯒꯤ ꯀꯟꯁꯦꯟꯠꯔꯦꯁꯅꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯐꯣꯔꯇꯤꯐꯥꯏ ꯇꯧꯏ꯫ ꯍꯥꯌꯔꯤꯕꯥ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯄꯣꯠꯂꯃꯁꯤꯡ ꯑꯁꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯌꯨꯝꯕꯤꯅꯤ꯫ ꯄ꯭ꯂꯂꯥꯍꯥꯐꯤꯜ®ꯒꯤ ꯅꯧꯅꯥ ꯁꯦꯃꯒꯠꯄꯥ ꯊꯧꯅꯥꯒꯤ

ꯄꯤ.ꯑꯦꯜ.ꯑꯦꯜ.ꯑꯦ.-ꯕꯤ-ꯄꯤ.ꯏ.ꯖꯤ.: ꯑꯅꯧꯕꯥ ꯑꯍꯣꯡꯕꯥ ꯑꯃꯥ ꯄꯨꯔꯀꯄꯥ

ꯒꯨꯋꯥꯍꯥꯇꯤ ꯑꯦꯃꯥ ꯕꯥꯏꯑꯣꯂꯣꯖꯤꯀꯦꯜ ꯇꯦꯛꯅꯣꯂꯣꯖꯤ ꯀꯣ., ꯂꯤꯃꯤꯇꯦꯗꯇꯥ, ꯑꯅꯧꯕꯥ ꯄꯨꯊꯣꯀꯄꯒꯤ ꯊꯧꯑꯣꯡ ꯑꯃꯒꯤ ꯈꯨꯠꯊꯥꯡꯗꯥ ꯄꯤ.ꯑꯦꯜ.ꯑꯦꯜ.ꯑꯦ.(ꯄꯣꯂꯤ-ꯑꯦꯜ-ꯂꯦꯛꯇꯤꯛ ꯑꯦꯁꯤꯗ) ꯍꯦꯅꯒꯠꯍꯅꯕꯒꯤ ꯃꯥꯡꯖꯤꯜ ꯊꯥꯔꯤ꯫ ꯑꯩꯈꯣꯌꯒꯤ ꯄ꯭ꯔꯣꯄꯔꯇꯤ ꯑꯦꯁ.ꯗꯤ.ꯑꯦ.ꯑꯦꯝ.ꯒꯤ ꯇꯦꯛꯅꯣꯂꯣꯖꯤ ꯁꯤꯖꯤꯟꯅꯗꯨꯅꯥ ꯑꯩꯈꯣꯌꯅꯥ ꯄꯤ.ꯑꯦꯜ.ꯑꯦꯜ.ꯑꯦ.ꯕꯨ ꯌꯨꯅꯤꯐꯣꯔꯝ, ꯁ꯭ꯐꯦꯔꯤꯀꯜ ꯄꯤ.ꯑꯦꯜ.ꯑꯦꯜ.ꯑꯦ.-ꯕꯤ.-ꯄꯤ.ꯏ.ꯖꯤ. 32 μM ± 6 μmꯒꯤ ꯃꯦꯗꯤꯌꯝ ꯄꯥꯔꯇꯤꯀꯜ ꯁꯥꯏꯖ ꯑꯃꯁꯨꯡ 20–45 μm ꯐꯥꯎꯕꯒꯤ ꯃꯥꯏꯛꯔꯣꯁ꯭ꯐꯤꯌꯥꯔ 95%ꯒꯤ ꯃꯊꯛꯇꯥ, PLLAHAFILL®ꯗꯥ ꯂꯩꯕꯥ PLLA ꯃꯥꯏꯛꯔꯣꯁ꯭ꯐꯤꯌꯥꯔꯁꯤꯡꯅꯥ ꯃꯇꯝ ꯁꯥꯡꯅꯥ ꯆꯠꯄꯥ ꯏꯐꯦꯛꯇ ꯑꯃꯥ ꯁꯣꯌꯗꯅꯥ ꯐꯪꯍꯜꯂꯤ꯫

ꯀ꯭ꯂꯥꯏꯑꯦꯟꯇ-ꯇꯦꯁ꯭ꯠ ꯇꯧꯔꯕꯥ ꯂꯣꯡ-ꯇꯔꯝ

ꯃꯥꯂꯦꯃꯒꯤ ꯀ꯭ꯂꯥꯏꯟꯇ ꯐꯤꯗꯕꯦꯛ ꯑꯁꯤꯅꯥ ꯂꯦꯞꯇꯅꯥ ꯔꯤꯄꯣꯔꯠ ꯇꯧꯔꯤ ꯃꯗꯨꯗꯤ ꯄ꯭ꯂꯂꯥꯍꯥꯐꯤꯜ®ꯅꯥ ꯁꯤꯡꯊꯥꯅꯤꯡꯉꯥꯏ ꯑꯣꯏꯕꯥ ꯂꯝꯕꯤ ꯑꯃꯥ ꯄꯤꯔꯤ, ꯃꯁꯤꯗꯥ ꯆꯍꯤ ꯲ ꯅꯠꯠꯔꯒꯥ ꯃꯁꯤꯒꯤ ꯃꯊꯛꯇꯥ ꯂꯩꯕꯥ ꯏꯐꯦꯛꯇꯁꯤꯡ ꯂꯩ꯫

pllahafill®: ꯀꯥꯟꯅꯕꯥ ꯐꯪꯕꯒꯤ ꯁꯤꯝꯐꯅꯤ ꯑꯃꯥ

1. ꯄ꯭ꯔꯤꯁꯤꯁꯟ ꯐꯤꯜꯂꯤꯡ: ꯄꯣꯠꯊꯣꯛ ꯊꯥꯗꯣꯀꯄꯒꯤ ꯈꯨꯗꯣꯡꯊꯤꯕꯥ ꯂꯩꯇꯅꯥ ꯍꯣꯠꯅꯕꯅꯥ ꯋꯥꯈꯜ ꯋꯥꯕꯥ ꯃꯄꯨꯡ ꯐꯥꯍꯜꯂꯤ꯫

2. ꯃꯍꯧꯁꯥꯒꯤ ꯑꯦꯁ꯭ꯇꯦꯇꯤꯛꯁ: ꯃꯉꯥꯜ ꯇ꯭ꯔꯥꯟꯁꯃꯤꯁꯟ ꯂꯩꯇꯕꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯃꯍꯧꯁꯥꯒꯤ ꯑꯣꯏꯕꯥ ꯃꯑꯣꯡꯗꯥ ꯎꯕꯥ ꯐꯪꯗꯕꯥ ꯐꯜ ꯑꯃꯥ ꯁꯣꯌꯗꯅꯥ ꯐꯪꯍꯜꯂꯤ꯫

3. ꯕꯥꯏꯑꯣꯀꯝꯄꯦꯇꯤꯕꯜ ꯑꯦꯕꯁꯣꯔꯄꯁꯟ: ꯇꯞꯅꯥ ꯇꯞꯅꯥ ꯑꯃꯁꯨꯡ ꯃꯍꯧꯁꯥꯒꯤ ꯑꯣꯏꯕꯥ ꯕ꯭ꯔꯦꯀꯗꯥꯎꯟ ꯑꯃꯁꯨꯡ ꯍꯀꯆꯥꯡꯅꯥ ꯁꯣꯀꯄꯥ꯫

4. ꯂꯣꯡ-ꯇꯔꯝ ꯗꯤꯁꯄꯥꯔꯁꯟ: ꯄꯤ.ꯑꯦꯜ.ꯑꯦꯜ.ꯑꯦ.-ꯕꯤ-ꯄꯤ.ꯏ.ꯖꯤ.

5. ꯈꯨꯗꯛꯀꯤ ꯑꯣꯏꯕꯥ ꯏꯝꯄꯦꯛꯇ: ꯀ꯭ꯔꯣꯁ-ꯂꯤꯉ꯭ꯛ ꯇꯧꯔꯕꯥ ꯍꯥꯏꯑꯦꯂꯨꯔꯣꯅꯤꯛ ꯑꯦꯁꯤꯗ ꯖꯦꯜ ꯌꯥꯎꯍꯅꯕꯅꯥ ꯈꯨꯗꯛꯇꯥ ꯎꯕꯥ ꯉꯝꯕꯥ ꯐꯤꯜꯂꯤꯡꯒꯤ ꯐꯂꯁꯤꯡ ꯄꯤ꯫

6. ꯑꯦꯛꯁꯇꯦꯟꯗ ꯇꯧꯔꯕꯥ ꯇꯨꯡ ꯀꯣꯏꯅꯥ ꯆꯠꯄꯥ ꯉꯝꯕꯥ: ꯍꯦꯟꯅꯥ ꯁꯥꯡꯅꯥ ꯆꯠꯄꯥ ꯏꯐꯦꯛꯇ ꯑꯃꯒꯤꯗꯃꯛ ꯗꯤꯖꯥꯏꯟ ꯇꯧꯕꯥ, ꯂꯦꯞꯇꯅꯥ ꯅꯍꯥ ꯑꯣꯏꯔꯤꯕꯥ ꯃꯑꯣꯡ ꯑꯃꯥ ꯁꯣꯌꯗꯅꯥ ꯂꯩꯍꯅꯕꯥ꯫

pllahafill® ꯑꯁꯤ ꯐꯦꯁꯤꯑꯦꯜ ꯔꯤꯚꯥꯏꯇꯦꯂꯥꯏꯖꯦꯁꯅꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯑꯅꯧꯕꯥ ꯋꯥꯈꯜꯂꯣꯟ ꯄꯣꯀꯍꯅꯕꯒꯤ ꯏꯄꯤꯇꯣꯃꯅꯤ, ꯃꯁꯤꯅꯥ ꯇꯁꯦꯡꯅꯥ ꯇ꯭ꯔꯥꯟꯁꯐꯣꯔꯃꯦꯇꯤꯕ ꯑꯦꯛꯁꯄꯔꯤꯌꯦꯟꯁ ꯑꯃꯒꯤꯗꯃꯛ ꯈꯨꯗꯛꯀꯤ ꯑꯣꯏꯕꯥ ꯑꯃꯁꯨꯡ ꯃꯇꯝ ꯁꯥꯡꯅꯥ ꯀꯥꯟꯅꯕꯥ ꯐꯪꯍꯜꯂꯤꯕꯥ ꯑꯄꯨꯅꯕꯥ ꯁꯣꯂꯨꯁꯟ ꯑꯃꯥ ꯄꯤꯔꯤ꯫

ꯄ꯭ꯂꯥꯍꯥꯐꯤꯜ®ꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯐꯦꯁꯤꯑꯦꯜ ꯀꯟꯇꯦꯅꯔꯁꯤꯡꯗꯥ ꯑꯍꯣꯡꯕꯥ ꯄꯨꯔꯀꯄꯥ:

pllahafill®ꯅꯥ ꯐꯦꯁꯤꯑꯦꯜ ꯑꯦꯁ꯭ꯇꯦꯇꯤꯛꯁꯇꯥ ꯑꯅꯧꯕꯥ ꯏꯄꯣꯛ ꯑꯃꯥ ꯍꯦꯔꯥꯜꯗ ꯇꯧꯏ, ꯃꯁꯤꯅꯥ ꯐꯦꯁ ꯍꯦꯅꯒꯠꯍꯟꯅꯕꯒꯤꯗꯃꯛꯇꯥ ꯏꯂꯤꯒꯦꯟꯇ ꯑꯃꯁꯨꯡ ꯁꯣꯐꯤꯁ꯭ꯇꯤꯀꯦꯠ ꯁ꯭ꯠꯔꯦꯇꯦꯖꯤ ꯑꯃꯥ ꯄꯤꯔꯤ꯫ ꯃꯁꯤꯒꯤ ꯑꯅꯧꯕꯥ ꯐꯤꯂꯔ ꯁꯤꯁ꯭ꯇꯦꯝ ꯑꯁꯤ ꯅ꯭ꯌꯨꯑꯦꯟꯁ ꯍꯦꯅꯒꯠꯍꯅꯕꯥ ꯑꯃꯁꯨꯡ ꯅꯧꯅꯥ ꯁꯦꯃꯒꯠꯄꯥ ꯄꯥꯝꯂꯤꯕꯥ ꯑꯀꯛꯅꯕꯥ ꯐꯦꯁꯤꯑꯦꯜ ꯑꯦꯔꯤꯌꯥꯁꯤꯡ ꯊꯦꯡꯅꯅꯕꯥ ꯅꯤꯡꯊꯤꯅꯥ ꯌꯦꯡꯁꯤꯅꯕꯥ ꯌꯥꯕꯥ ꯀꯦꯌꯔꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯁꯦꯃꯈꯤꯕꯅꯤ꯫

• ꯃꯟꯗꯤꯔ ꯍꯦꯅꯒꯠꯍꯅꯕꯥ: ꯄ꯭ꯂꯥꯍꯥꯐꯤꯜ®ꯅꯥ ꯃꯟꯗꯤꯔꯁꯤꯡ ꯑꯁꯤ ꯇꯞꯅꯥ ꯇꯞꯅꯥ ꯔꯤꯐꯥꯏꯟꯅꯥ ꯇꯧꯏ, ꯃꯁꯤꯅꯥ ꯑꯄꯨꯅꯕꯥ ꯐꯦꯁꯤꯑꯦꯜ ꯑꯥꯔꯀꯤꯇꯦꯀꯆꯔꯗꯥ ꯆꯥꯡ ꯃꯥꯟꯅꯕꯥ ꯑꯃꯁꯨꯡ ꯅꯨꯡꯁꯤꯅꯥ ꯏꯟꯇꯤꯒ꯭ꯔꯦꯁꯟ ꯑꯃꯥ ꯐꯪꯍꯜꯂꯤ꯫

• ꯕ꯭ꯔꯥꯎ ꯕꯣꯟ ꯏꯂꯦꯛꯠꯔꯤꯁꯤꯇꯤ: ꯕ꯭ꯔꯥꯎ ꯕꯣꯟ ꯑꯁꯤ ꯐꯥꯏꯅꯦꯁꯅꯥ ꯋꯥꯡꯈꯠꯍꯜꯂꯤ, ꯃꯁꯤꯅꯥ ꯍꯦꯟꯅꯥ ꯃꯌꯦꯛ ꯁꯦꯡꯕꯥ ꯑꯃꯁꯨꯡ ꯅꯍꯥ ꯑꯣꯏꯔꯤꯕꯥ ꯕ꯭ꯔꯥꯎ ꯂꯥꯏꯟ ꯑꯃꯥ ꯁꯦꯝ-ꯁꯥꯗꯨꯅꯥ ꯐꯖꯅꯥ ꯐ꯭ꯔꯦꯝ ꯇꯧꯏ꯫

• ꯅꯥꯀꯣꯡꯒꯤ ꯀꯟꯇꯨꯔꯤꯡ: ꯄ꯭ꯔꯤꯁꯤꯁꯟ ꯑꯁꯤ ꯅꯥꯀꯣꯡꯒꯤ ꯔꯤꯐꯥꯏꯅꯤꯡꯗꯥ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯑꯃꯅꯤ, ꯃꯁꯤꯅꯥ ꯃꯍꯧꯁꯥꯒꯤ ꯑꯣꯏꯕꯥ ꯑꯃꯁꯨꯡ ꯃꯤꯠꯀꯤ ꯅꯨꯡꯉꯥꯏꯕꯥ ꯑꯅꯤꯃꯛ ꯑꯣꯏꯕꯥ ꯁꯤꯂꯍꯧ ꯑꯃꯥ ꯁꯣꯌꯗꯅꯥ ꯂꯩꯍꯜꯂꯤ꯫

• ꯀꯣꯂꯝ ꯅꯥꯁꯤ ꯁꯦꯄꯤꯡ: ꯀꯣꯂꯝ, ꯅꯥꯀꯣꯡꯒꯤ ꯁꯦꯟꯠꯔꯦꯜ ꯄꯤꯂꯔ ꯑꯁꯤ ꯐꯦꯁꯤꯑꯦꯜ ꯍꯥꯔꯃꯣꯅꯤ ꯍꯦꯅꯒꯠꯍꯜꯂꯤꯕꯥ ꯔꯤꯐꯥꯏꯟꯅꯥ ꯁꯦꯝꯕꯥ ꯁꯤꯃꯦꯠꯔꯤ ꯑꯃꯥ ꯐꯪꯅꯕꯒꯤꯗꯃꯛ ꯑꯥꯔꯇꯀꯤ ꯑꯣꯏꯕꯥ ꯃꯑꯣꯡꯗꯥ ꯁꯦꯝꯕꯅꯤ꯫

• ꯆꯤꯟ ꯍꯦꯅꯒꯠꯍꯅꯕꯥ: ꯆꯤꯟ ꯑꯁꯤꯅꯥ ꯃꯌꯦꯛ ꯁꯦꯡꯕꯥ ꯍꯦꯅꯒꯠꯍꯅꯕꯥ, ꯈꯣꯡꯗꯥ ꯋꯥꯍꯟꯊꯣꯛ ꯍꯥꯄꯆꯤꯜꯂꯤ ꯑꯃꯁꯨꯡ ꯕꯦꯂꯦꯟꯁ ꯑꯣꯏꯕꯥ ꯚꯤꯖꯥꯖ ꯑꯃꯥ ꯁꯦꯝꯃꯤ꯫

• ꯑꯦꯝ.ꯑꯦ.ꯑꯦꯜ.ꯑꯦ.ꯑꯥꯔ.ꯒꯤ ꯔꯤꯖꯟ ꯁꯄꯣꯔꯠ: ꯑꯦꯝ.ꯑꯦ.ꯑꯦꯜ.ꯑꯦ.ꯑꯥꯔ.ꯒꯤ ꯔꯤꯖꯅꯗꯥ ꯁꯄꯣꯔꯠ ꯄꯤꯔꯤ, ꯂꯤꯐꯠ ꯑꯃꯁꯨꯡ ꯀꯟꯇꯨꯔ ꯇꯧꯔꯕꯥ ꯆꯦꯛꯁꯤꯟ-ꯊꯧꯔꯥꯡꯁꯤꯡ ꯁꯣꯌꯗꯅꯥ ꯂꯩꯍꯜꯂꯤ, ꯅꯍꯥ ꯑꯣꯏꯔꯤꯕꯥ ꯒ꯭ꯂꯣꯕ ꯑꯃꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫

ꯑꯩꯈꯣꯌꯒꯤ ꯚꯤꯖꯨꯑꯦꯜ ꯅꯦꯔꯦꯇꯤꯕꯀꯤ ꯏꯚꯣꯀꯦꯇꯤꯕ ꯂꯦꯟꯁꯀꯤ ꯈꯨꯠꯊꯥꯡꯗꯥ ꯂꯧꯈꯠꯂꯀꯄꯥ ꯑꯩꯈꯣꯌꯒꯤ ꯗꯤꯁ꯭ꯇꯤꯡꯁꯟ ꯀ꯭ꯂꯥꯏꯟꯇꯂꯒꯤ ꯇ꯭ꯔꯥꯟꯁꯐꯣꯔꯃꯦꯇꯤꯕ ꯑꯦꯛꯁꯄꯔꯤꯑꯦꯟꯁꯁꯤꯡꯗꯥ ꯊꯤꯖꯤꯜꯂꯨ꯫ ꯄ꯭ꯂꯥꯍꯥꯐꯤꯜ®ꯅꯥ ꯆꯍꯤ ꯇꯔꯥꯒꯤ ꯈꯨꯖꯤꯡ ꯑꯅꯤ ꯑꯃꯁꯨꯡ ꯃꯁꯤꯗꯒꯤ ꯍꯦꯅꯕꯥ ꯃꯇꯃꯗꯥ ꯃꯈꯣꯌꯒꯤ ꯀꯥꯟꯅꯕꯥ ꯐꯪꯕꯁꯤꯡ ꯑꯗꯨ ꯐꯪꯈꯤꯕꯥ ꯃꯤꯑꯣꯏꯁꯤꯡꯒꯤ ꯑꯄꯨꯅꯕꯥ ꯑꯦꯐꯤꯃꯦꯁꯅꯁꯤꯡꯅꯥ ꯃꯈꯥ ꯄꯣꯜꯂꯤꯕꯥ ꯂꯦꯡꯗꯕꯥ ꯑꯦꯛꯁꯦꯂꯦꯟꯁ ꯑꯃꯁꯨꯡ ꯏꯐꯤꯁꯤꯑꯦꯟꯁꯤꯒꯤ ꯃꯁꯛ ꯑꯃꯥ ꯑꯣꯏꯅꯥ ꯊꯣꯔꯀꯈꯤ꯫

ꯃꯥꯂꯦꯃꯒꯤ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯂꯥꯞꯄꯥ ꯃꯐꯃꯁꯤꯡꯗꯒꯤ ꯂꯥꯀꯄꯥ ꯑꯩꯈꯣꯌꯒꯤ ꯀ꯭ꯂꯥꯏꯟꯇꯜ ꯑꯁꯤꯅꯥ ꯃꯃꯤꯡ ꯂꯩꯔꯕꯥ ꯆꯍꯤ ꯲꯱ ꯍꯦꯟꯅꯥ ꯆꯠꯊꯔꯀꯄꯥ ꯐꯤꯗꯕꯦꯀꯀꯤ ꯔꯤꯆ ꯇꯦꯄꯦꯁ꯭ꯠꯔꯤ ꯑꯃꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯂꯤ꯫

ꯒꯨꯋꯥꯍꯥꯇꯤ ꯑꯦꯃꯥ ꯕꯥꯏꯑꯣꯂꯣꯖꯤꯀꯦꯜ ꯇꯦꯛꯅꯣꯂꯣꯖꯤ ꯀꯣ., ꯂꯤꯃꯤꯇꯦꯗꯇꯥ, ꯑꯩꯈꯣꯌꯅꯥ ꯑꯗꯣꯃꯒꯤ ꯁ꯭ꯕꯤꯐ ꯑꯃꯁꯨꯡ ꯁꯦꯛꯌꯨꯔ ꯑꯣꯏꯕꯥ ꯂꯣꯖꯤꯁ꯭ꯇꯤꯛꯁꯀꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯑꯗꯨ ꯈꯉꯏ꯫ pllahafill® ꯍꯥꯏꯑꯦꯂꯨꯔꯣꯅꯤꯛ ꯑꯦꯁꯤꯗ ꯐꯤꯂꯔꯒꯤꯗꯃꯛ ꯑꯩꯈꯣꯌꯒꯤ ꯀꯃꯤꯠꯃꯦꯟꯇ ꯑꯁꯤꯅꯥ ꯑꯗꯣꯃꯒꯤ ꯄꯣꯠꯊꯣꯛ ꯑꯗꯨꯒꯤ ꯄ꯭ꯔꯤꯁ꯭ꯇꯤꯟ ꯗꯦꯂꯤꯕꯔꯤꯒꯤ ꯒꯔꯦꯟꯇꯤ ꯄꯤꯔꯤꯕꯥ ꯊꯥꯖꯕꯥ ꯌꯥꯕꯥ ꯁꯤꯄꯤꯡ ꯁꯣꯂꯨꯁꯅꯁꯤꯡ ꯄꯤꯕꯗꯥ ꯌꯧꯍꯜꯂꯤ꯫

ꯔꯦꯄꯤꯗ ꯑꯦꯌꯔ ꯐ꯭ꯔꯦꯠ ꯁꯔꯚꯤꯁꯁꯤꯡ:

ꯗꯤ.ꯑꯩꯆ.ꯑꯦꯜ., ꯐꯦꯗꯑꯦꯛꯁ, ꯅꯠꯠꯔꯒꯥ ꯌꯨ.ꯄꯤ.ꯑꯦꯁ.ꯒꯨꯝꯕꯥ ꯃꯥꯡꯖꯤꯜ ꯊꯥꯔꯤꯕꯥ ꯀꯦꯔꯤꯌꯔꯁꯤꯡꯒꯥ ꯈꯨꯠꯁꯝꯅꯗꯨꯅꯥ ꯑꯩꯈꯣꯌꯒꯤ ꯈꯣꯡꯖꯦꯜ ꯌꯥꯡꯅꯥ ꯑꯦꯌꯔ ꯐ꯭ꯔꯦꯠ ꯁꯔꯕꯤꯁ ꯑꯁꯤꯅꯥ ꯅꯨꯃꯤꯠ ꯳-꯶ꯅꯤꯒꯤ ꯌꯥꯝꯅꯥ ꯊꯨꯅꯥ ꯌꯧꯍꯅꯕꯒꯤ ꯎꯏꯟꯗꯣ ꯑꯃꯥ ꯄꯤꯒꯅꯤ ꯍꯥꯌꯅꯥ ꯋꯥꯁꯀꯄꯤꯔꯤ꯫ ꯃꯁꯤꯒꯤ ꯑꯣꯄꯁꯟ ꯑꯁꯤ ꯇꯦꯝꯄꯦꯔꯦꯆꯔ-ꯁꯦꯟꯁꯤꯇꯤꯕ ꯑꯣꯏꯕꯥ ꯄꯣꯠꯊꯣꯀꯁꯤꯡ ꯊꯥꯗꯣꯀꯄꯒꯤꯗꯃꯛꯇꯥ ꯌꯥꯝꯅꯥ ꯐꯖꯅꯥ ꯁꯦꯝ ꯁꯥꯕꯅꯤ, ꯃꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ PLLAHAFILL®ꯒꯤ ꯃꯒꯨꯟ ꯑꯗꯨ ꯈꯣꯉꯆꯠ ꯄꯨꯝꯅꯃꯛꯇꯥ ꯅꯤꯡꯊꯤꯅꯥ ꯉꯥꯛꯇꯨꯅꯥ ꯊꯝꯂꯤ꯫

ꯀꯁ꯭ꯇꯃꯔ ꯂꯣꯖꯤꯁ꯭ꯇꯤꯛꯁꯀꯤ ꯑꯦꯛꯁꯄꯔꯤꯌꯦꯟꯁ:

ꯑꯩꯈꯣꯌꯅꯥ ꯄꯔꯁꯣꯅꯦꯂꯥꯏꯖ ꯇꯧꯔꯕꯥ ꯁꯔꯕꯤꯁꯀꯤ ꯃꯒꯨꯟ ꯑꯗꯨ ꯈꯉꯏ, ꯃꯔꯝ ꯑꯁꯤꯅꯥ ꯑꯩꯈꯣꯌꯅꯥ ꯑꯗꯣꯃꯒꯤ ꯑꯈꯟꯅꯕꯥ ꯁꯤꯄꯤꯡꯒꯤ ꯃꯊꯧ ꯇꯥꯕꯁꯤꯡ ꯑꯗꯨ ꯐꯪꯍꯟꯅꯕꯥ ꯀꯁ꯭ꯇꯝ ꯂꯣꯖꯤꯁ꯭ꯇꯤꯛꯁ ꯁꯣꯂꯨꯁꯅꯁꯤꯡ ꯄꯤꯔꯤ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯆꯥꯏꯅꯥꯗꯥ ꯆꯣꯏꯁ ꯑꯣꯐ ꯆꯣꯏꯁ ꯑꯃꯥ ꯂꯩꯔꯕꯗꯤ, ꯑꯩꯈꯣꯌꯗꯥ ꯅꯍꯥꯛꯀꯤ ꯄꯁꯟꯗꯒꯤ ꯄꯥꯎ ꯐꯥꯑꯣꯅꯕꯤꯌꯨ, ꯑꯃꯁꯨꯡ ꯑꯩꯈꯣꯌꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯦꯖꯤꯒꯅꯦꯇꯦꯗ ꯑꯦꯖꯦꯟꯁꯤꯒꯤ ꯈꯨꯠꯊꯥꯡꯗꯥ ꯁꯤꯄꯃꯦꯟꯇ ꯑꯗꯨ ꯀꯣꯑꯣꯔꯗꯤꯅꯦꯠ ꯇꯧꯒꯅꯤ, ꯑꯃꯁꯨꯡ ꯇꯦꯜꯂꯔ ꯂꯣꯖꯤꯁ꯭ꯇꯤꯛꯁ ꯑꯦꯛꯁꯄꯤꯔꯤꯑꯦꯟꯁ ꯑꯃꯥ ꯄꯤꯒꯅꯤ꯫

ꯇꯦꯝꯄꯦꯔꯦꯆꯔ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯕꯥ ꯁꯤꯄꯤꯡꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ:

ꯃꯦꯗꯤꯀꯦꯜ ꯑꯦꯁ꯭ꯇꯦꯇꯤꯛ ꯄꯣꯠꯊꯣꯀꯁꯤꯡꯒꯤ ꯑꯀꯅꯕꯥ ꯇꯦꯝꯄꯦꯔꯦꯆꯔ ꯁ꯭ꯄꯦꯁꯤꯐꯤꯀꯦꯁꯅꯁꯤꯡ ꯑꯁꯤ ꯌꯦꯡꯂꯒꯥ, ꯑꯩꯈꯣꯌꯅꯥ ꯄꯣꯠꯂꯃꯁꯤꯡ ꯑꯁꯤꯒꯤꯗꯃꯛꯇꯥ ꯁꯃꯨꯗ꯭ꯔꯒꯤ ꯆꯠꯊꯣꯛ-ꯆꯠꯁꯤꯅꯒꯤ ꯃꯥꯌꯣꯛꯇꯥ ꯀꯟꯅꯥ ꯇꯀꯁꯤꯜꯂꯤ꯫ ꯑꯩꯈꯣꯌꯒꯤ ꯄꯥꯎꯇꯥꯀꯁꯤꯡ ꯑꯁꯤ ꯑꯗꯣꯃꯒꯤ ꯏꯟꯇꯤꯒ꯭ꯔꯤꯇꯤ ꯑꯃꯁꯨꯡ ꯏꯐꯤꯁꯤꯑꯦꯟꯁꯤ ꯉꯥꯛꯇꯨꯅꯥ ꯊꯝꯅꯕꯥ ꯑꯩꯈꯣꯌꯒꯤ ꯂꯦꯞꯄꯥ ꯂꯩꯇꯕꯥ ꯋꯥꯁꯛ ꯑꯗꯨꯅꯥ ꯊꯧꯒꯠꯂꯤ pllahafill® ꯍꯥꯏꯑꯦꯂꯨꯔꯣꯅꯤꯛ ꯑꯦꯁꯤꯗ ꯐꯤꯂꯔꯒꯤ , ꯃꯁꯤꯅꯥ ꯑꯗꯣꯃꯗꯥ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯐꯕꯥ ꯐꯤꯚꯃꯗꯥ ꯌꯧꯍꯅꯕꯥ ꯉꯃꯍꯜꯂꯤ꯫

ꯒꯨꯋꯥꯍꯥꯇꯤ ꯑꯦ.ꯑꯣ.ꯑꯦꯝ.ꯑꯣ.ꯒꯤ ꯕꯥꯏꯑꯣꯂꯣꯖꯤꯀꯦꯜ ꯇꯦꯛꯅꯣꯂꯣꯖꯤ ꯀꯣ., ꯂꯤꯃꯤꯇꯦꯗ. ꯑꯁꯤ ꯁꯦꯛꯌꯨꯔ ꯑꯣꯏꯕꯥ ꯄꯦꯃꯦꯟꯇ ꯑꯣꯄꯁꯅꯁꯤꯡꯒꯤ ꯐ꯭ꯂꯦꯛꯁꯤꯕꯜ ꯑꯦꯔꯦ ꯑꯃꯥ ꯄꯤꯅꯕꯒꯤꯗꯃꯛ ꯀꯠꯊꯣꯛꯂꯤ, ꯃꯁꯤꯅꯥ ꯑꯩꯈꯣꯌꯒꯤ ꯀꯁ꯭ꯇꯃꯔꯁꯤꯡꯅꯥ ꯃꯈꯣꯌꯒꯤ ꯗꯔꯀꯥꯔ ꯑꯣꯏꯕꯁꯤꯡ ꯑꯗꯨ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯐꯕꯥ ꯃꯑꯣꯡꯗꯥ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯐꯕꯥ ꯃꯑꯣꯡꯗꯥ ꯈꯅꯕꯤꯕꯥ ꯉꯃꯒꯅꯤ ꯍꯥꯌꯕꯁꯤ ꯁꯣꯌꯗꯅꯥ ꯈꯉꯗꯣꯀꯏ:

꯱.ꯀꯥꯔꯗ ꯄ꯭ꯔꯣꯁꯦꯁꯤꯡ ꯑꯁꯤ ꯐꯖꯅꯥ ꯇꯧꯕꯥ .

ꯑꯩꯈꯣꯌꯒꯤ ꯀ꯭ꯔꯦꯗꯤꯠ ꯑꯃꯁꯨꯡ ꯗꯦꯕꯤꯠ ꯀꯥꯔꯗ ꯄ꯭ꯔꯣꯁꯦꯁꯤꯡ ꯁꯔꯚꯤꯁꯀꯥ ꯂꯣꯌꯅꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯄꯦꯃꯦꯟꯇ ꯄ꯭ꯔꯣꯁꯦꯁ ꯑꯗꯨ ꯂꯥꯏꯊꯣꯀꯍꯜꯂꯨ꯫ ꯅꯍꯥꯛꯅꯥ ꯄꯥꯝꯂꯤꯕꯥ ꯀꯥꯔꯗ ꯑꯗꯨ ꯁꯤꯖꯤꯟꯅꯗꯨꯅꯥ, ꯄꯨꯝꯅꯃꯛ ꯑꯁꯤ ꯑꯩꯈꯣꯌꯒꯤ ꯑꯆꯦꯠꯄꯥ ꯁꯦꯛꯌꯨꯔꯤꯇꯤꯒꯤ ꯊꯧꯔꯥꯡꯁꯤꯡꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯂꯥꯀꯄꯥ ꯋꯥꯈꯂꯒꯤ ꯁꯥꯟꯇꯤ ꯑꯗꯨ ꯅꯨꯡꯉꯥꯏꯅꯥ ꯂꯧꯕꯒꯥ ꯂꯣꯌꯅꯅꯥ, ꯄꯨꯝꯅꯃꯛ ꯑꯁꯤ ꯅꯤꯡꯊꯤꯖꯅꯥ ꯑꯃꯁꯨꯡ ꯁꯦꯛꯌꯨꯑꯣꯔ ꯑꯣꯏꯕꯥ ꯇ꯭ꯔꯥꯟꯖꯦꯛꯁꯟ ꯑꯃꯥ ꯑꯦꯛꯁꯄꯔꯤꯌꯦꯟꯁ ꯇꯧꯕꯤꯌꯨ꯫

꯲.ꯁ꯭ꯕꯤꯐ꯭ꯠ ꯕꯦꯉ꯭ꯛ ꯇ꯭ꯔꯥꯟꯁꯐꯔ ꯇꯧꯕꯥ  

ꯗꯥꯏꯔꯦꯛꯇ ꯑꯦꯞꯔꯣꯆ ꯑꯃꯥ ꯄꯥꯝꯂꯤꯕꯁꯤꯡꯒꯤꯗꯃꯛꯇꯥ, ꯑꯩꯈꯣꯌꯒꯤ ꯏꯟꯁꯇꯦꯟꯇ ꯕꯦꯉ꯭ꯛ ꯇ꯭ꯔꯥꯟꯁꯐꯔ ꯑꯣꯄꯁꯟ ꯑꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯄꯦꯃꯦꯟꯇ ꯑꯗꯨ ꯃꯄꯨꯡ ꯐꯥꯍꯟꯅꯕꯒꯤ ꯈꯣꯡꯖꯦꯜ ꯑꯃꯁꯨꯡ ꯏꯐꯤꯁꯤꯑꯦꯟꯇ ꯑꯣꯏꯕꯥ ꯃꯑꯣꯡ ꯑꯃꯥ ꯄꯤꯔꯤ꯫ ꯃꯁꯤꯒꯤ ꯄꯥꯝꯕꯩ ꯑꯁꯤ ꯃꯈꯣꯌꯒꯤ ꯁꯦꯜ-ꯊꯨꯃꯒꯤ ꯇ꯭ꯔꯥꯟꯖꯦꯛꯁꯅꯁꯤꯡꯗꯥ ꯈꯣꯡꯖꯦꯜ ꯑꯃꯁꯨꯡ ꯂꯥꯏꯅꯥ ꯑꯁꯤꯕꯨ ꯃꯃꯜ ꯌꯥꯝꯅꯥ ꯊꯝꯂꯤꯕꯥ ꯀꯁ꯭ꯇꯃꯔꯁꯤꯡꯒꯤꯗꯃꯛ ꯁꯦꯃꯈꯤꯕꯅꯤ꯫

꯳.ꯃꯣꯕꯥꯏꯜ ꯄꯦꯃꯦꯟꯇ ꯏꯅꯣꯕꯦꯁꯟ ꯳.  

ꯅꯍꯥꯛꯀꯤ ꯄꯦꯃꯦꯟꯇꯁꯤꯡ ꯑꯗꯨ ꯁꯦꯇꯜ ꯇꯧꯅꯕꯥ ꯃꯣꯕꯥꯏꯜ ꯄꯦꯃꯦꯟꯇ ꯑꯦꯞꯂꯤꯀꯦꯁꯅꯁꯤꯡꯒꯤ ꯈꯨꯗꯣꯡꯆꯥꯕꯥ ꯂꯧꯕꯒꯤ ꯀꯥꯟꯅꯕꯥ ꯂꯧꯕꯤꯌꯨ꯫ ꯑꯩꯈꯣꯌꯒꯤ ꯁꯤꯁ꯭ꯇꯦꯝ ꯑꯁꯤꯅꯥ ꯃꯣꯕꯥꯏꯜ ꯄꯦꯃꯦꯟꯇ ꯁꯣꯂꯨꯁꯟ ꯀꯌꯥ ꯑꯃꯥ ꯁꯄꯣꯔꯠ ꯇꯧꯏ, ꯃꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯁ꯭ꯃꯥꯔꯇꯐꯣꯟ ꯅꯠꯠꯔꯒꯥ ꯇꯦꯕꯂꯗꯒꯤ ꯍꯀꯊꯦꯡꯅꯅꯥ ꯊꯨꯅꯥ ꯑꯃꯁꯨꯡ ꯍꯣꯠꯅꯗꯕꯥ ꯆꯦꯀꯑꯥꯎꯠ ꯑꯦꯛꯁꯄꯤꯔꯤꯑꯦꯟꯁ ꯑꯃꯥ ꯁꯣꯌꯗꯅꯥ ꯐꯪꯍꯜꯂꯤ꯫

꯴.ꯂꯣꯀꯦꯂꯥꯏꯖ ꯄꯦꯃꯦꯟꯇ ꯑꯦꯛꯁꯄꯤꯔꯤꯑꯦꯟꯁ ꯂꯩꯕꯥ .  

ꯑꯩꯈꯣꯌꯒꯤ ꯃꯥꯂꯦꯃꯒꯤ ꯀ꯭ꯂꯥꯏꯟꯇꯂꯗꯥ ꯀꯦꯇꯦꯔꯤꯡ ꯇꯧꯕꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯑꯗꯨ ꯈꯉꯂꯗꯨꯅꯥ ꯑꯩꯈꯣꯌꯅꯥ ꯃꯤꯌꯥꯝꯅꯥ ꯄꯥꯝꯅꯕꯥ ꯔꯤꯖꯅꯦꯜ ꯄꯦꯃꯦꯟꯇ ꯃꯦꯊꯗꯁꯤꯡ ꯈꯅꯒꯠꯂꯕꯥ ꯑꯃꯥ ꯄꯤꯔꯤ꯫ ꯃꯁꯤꯗꯥ ꯌꯥꯑꯣꯔꯤ, ꯑꯗꯨꯕꯨ ꯃꯁꯤꯗꯥ ꯂꯤꯃꯤꯠ ꯂꯩꯇꯦ, ꯑꯥꯐꯇꯔꯄꯦ, ꯄꯦ-ꯐꯖ, ꯃꯣꯂꯄꯥꯏ, ꯑꯃꯁꯨꯡ ꯕꯣꯂꯦꯇꯣ, ꯑꯩꯈꯣꯌꯒꯤ ꯀꯁ꯭ꯇꯃꯔꯁꯤꯡꯅꯥ ꯃꯈꯣꯌꯗꯥ ꯈꯉꯅꯔꯕꯥ ꯑꯃꯁꯨꯡ ꯈꯨꯗꯣꯡꯆꯥꯕꯥ ꯑꯅꯤꯃꯛ ꯄꯤꯕꯥ ꯉꯝꯕꯥ ꯃꯑꯣꯡꯗꯥ ꯄꯤꯕꯥ ꯉꯃꯒꯅꯤ꯫

ꯒꯨꯋꯥꯍꯥꯇꯤ ꯑꯦꯃꯥ ꯕꯥꯏꯑꯣꯂꯣꯖꯤꯀꯦꯜ ꯇꯦꯛꯅꯣꯂꯣꯖꯤ ꯀꯣ., ꯂꯤꯃꯤꯇꯦꯗꯇꯥ, ꯑꯩꯈꯣꯌꯅꯥ ꯑꯩꯈꯣꯌꯒꯤ ꯀꯁ꯭ꯇꯃꯔ ꯕꯦꯖꯒꯨꯝꯕꯥ ꯇꯣꯉꯥꯟ ꯇꯣꯉꯥꯅꯕꯥ ꯄꯦꯃꯦꯟꯇ ꯄ꯭ꯔꯣꯁꯦꯁ ꯑꯃꯥ ꯁꯦꯝꯅꯕꯥ ꯍꯣꯠꯅꯔꯤ, ꯃꯁꯤꯅꯥ ꯇ꯭ꯔꯥꯟꯖꯦꯛꯁꯟ ꯈꯨꯗꯤꯡꯃꯛꯀꯤ ꯄꯔꯁꯣꯅꯦꯂꯥꯏꯖ ꯑꯃꯁꯨꯡ ꯁꯦꯛꯌꯨꯔ ꯑꯣꯏꯕꯥ ꯑꯦꯛꯁꯄꯔꯤꯌꯦꯟꯁ ꯑꯃꯥ ꯁꯣꯌꯗꯅꯥ ꯐꯪꯍꯜꯂꯤ꯫