Kunenepa kwambiri kwakhala mliri wapadziko lonse, wokhudza anthu mamiliyoni ambiri padziko lonse lapansi. Ngakhale kuti ndalama zambiri zothetsa mavuto omwe alipo, anthu ambiri amavutika kuti akwaniritse komanso kukhala ndi kulemera kwawo. Komabe, kupita kwapa tsopano kwa sayansi ya zamankhwala kwapangitsa njira yolonjeza chithandizo cholonjeza, monga jakisoni wa semaglutide. Uko jakisoni uja watuluka ngati wange pa nkhondo yolimbana ndi kunenepa kwambiri, kupereka njira yothandiza kwambiri komanso yothandiza kwambiri yochepetsera thupi komanso kuwongolera kwa chakudya.
Munkhaniyi, tidzasamalira zabwino za Ma jakisoni a semaglutide , onani momwe amagwirira ntchito, ndipo kambiranani kuthekera kwawo kusintha miyoyo ya omwe akuvutika ndi kunenepa kwambiri. Kaya ndinu akatswiri azaumoyo ofunafuna zomwe ali nazo chifukwa cha odwala anu kapena munthu amene akufuna kuwongolera thupi lanu, nkhaniyi ithandizanso kuipitsa mphamvu ya jekeseni wokhazikika ndikusintha thanzi.
Kumvetsetsa semagluutide ndi makina ake ochita
Semagulitide ndi chinthu chopangidwa ndi matenda a Glucagon cha anthu - monga peptide-1 (glorp-1) mahomoni, omwe amatenga gawo lofunikira pakuwongolera kudya ndi magazi. Poyambirira zidapangidwa ngati mankhwala a shuga 2, koma mphamvu zake zodabwitsa zolemetsa zidakopa chidwi cha ofufuza ndi akatswiri azaumoyo.
Mukalowetsedwa m'thupi, semaglitside masics chochitika cha glop-1, cholimbikitsira kutulutsidwa kwa insulin ndikulepheretsa kutchinjiriza kwa glucagon. Chilichonse chochita chiwonetserochi chimathandiza kuchepetsa shuga ndi kulimbikitsa kuchepa thupi pochepetsa kulakalaka komanso kukulitsa kumva bwino. Semaglutide imachepetsa kuthira chapamimba, kuphatikizaponso kwa chipwirikiti.
Mayesero azachipatala asonyeza kufunika kwa semaglutdide pakulimbikitsa kuchepa thupi. Mu kafukufuku yemwe adafalitsidwa ku New England Journal of Medictic, omwe atenga nawo mbali omwe adalandira jakisoni wa Spemagluutide adapeza kuchepa kwa mphindi 68, poyerekeza ndi 2.4% mu gulu la placebo. Zotsatirazi zasangalala kwambiri mudokotala komanso pakati pa anthu omwe akuvutika ndi kunenepa kwambiri, chifukwa Semaglinutide imapereka njira yothandiza kwambiri komanso yothandiza kwambiri yoyang'anira thupi.
Ubwino wa jamagline wa semaglutide pakuchepetsa thupi
Chimodzi mwazopindulitsa kwambiri Ma jakisoni a semaglutide ndi kuthekera kwawo kulimbikitsa komanso kufooka. Mosiyana ndi mankhwala ena ambiri ochepetsa thupi omwe amapereka zotsatira kwakanthawi, semaglutide yawonetsedwa kuti ithandizire kukhala olemera nthawi yayitali.
Izi ndizofunikira kwambiri chifukwa ndalama zambiri zimakhala zovuta kwa iwo omwe alephera kunenepa komanso kuchita masewera olimbitsa thupi okha. Ndili ndi semaglitide, anthu amatha kukwanitsa kuwonongeka kwawo ndikupitilizabe kupita patsogolo, zomwe zimapangitsa kuti zitheke bwino thanzi komanso moyo wabwino.
Kuphatikiza apo, jakisoni wa semaglide umapereka njira yosavuta komanso yosavuta yogwiritsira ntchito kulemera. Kutumikiridwa kamodzi pa sabata kudzera mu jakisoni wocheperako, semaguglide imachotsa kufunika kwa dokotala wochita madotolo pafupipafupi kapena kuwongolera chithandizo chamankhwala. Kuthekera kumeneku kumapangitsa kuti ikhale njira yokongoletsera anthu omwe angakumane ndi kutsatira kwina kwa thupi.
Kuphatikiza apo, Semaglutide wawonetsedwa kukhala ndi mbiri yabwino, ndi ambiri mwa omwe ali mu mayesero azachipatala omwe akuyembekeza kungobwezeretsa mavuto. Zotsatira zoyipa izi, monga nseru ndi kutsegula m'mimba, nthawi zambiri zimakhala zosakhazikika ndikutsimikiza ndi chithandizo chopitilira. Pafupifupi, mapindu a jamugluty jakisoni pakuchepetsa, kupereka njira yothandiza kwambiri komanso yosavuta kwa anthu omwe akufuna kuwongolera kulemera kwawo ndikusintha thanzi lawo.
Momwe Semaglitride imathandizira kuwongolera chidwi ndi zilakolako
Chimodzi mwazinthu zazikulu zomwe zimathandizira kunenepa kwambiri ndikupezeka kwa njala ndi zolakalaka, zomwe zimatha kusokoneza ngakhale zoyeserera zolemetsa kwambiri. Semaglunutdide amafotokoza bwino za nkhaniyi mwakufunafuna malo a ubongo, kuthandiza kuchepetsa nkhawa komanso zopindika.
Kafukufuku wasonyeza kuti jekeseni wa semaglutide amatha kuchepetsa kwambiri chikhumbo chofuna kudya, makamaka zakudya zapamwamba komanso zakudya zonenepa. Zotsatirazi zimaganiziridwa kuti zimalumikizidwa kudzera mu kutsegula kwa ma rep-1 mu ubongo, yomwe imasinthasintha kumasulidwa kwa ma neurotransmitter omwe akukhudzidwa ndi chikhumbo cha chidwi.
Mwa kuwongolera chilakolako cha chilakolako ndi zolakalaka, semagugling imathandiza anthu kuti apange zosankha zathanzi ndikutsatira zakudya zochepetsedwa - kalori zambiri. Izi, zimapangitsa kuti izi zitheke kuchepetsedwa komanso kuwongolera thanzi labwino. Kuphatikiza apo, zotsatira zopatsa chidwi za semaglutide zimatalika kupitirira kutalika kwa jakisoni, kumathandiza kukhazikitsa mapangidwe ndi miyambo pakapita nthawi yayitali.
Kwa anthu omwe akuvutika ndi zovuta zakudya m'maganizo kapena kuphatikizika kwa kudya, semaguglutide ikhoza kupereka chida chofunikira kwambiri chophwanya nthawi yodyera kwambiri ndikukwaniritsa kusintha kosatha. Mwa kutchulapo zinthu zachilengedwe zomwe zimayendetsa machitidwewa, jakisoni wa Semaglutide amapereka njira yathunthu yoyang'anira kulemera komwe kumadutsa kalori kalori kuwerengera kapena kuchita masewera olimbitsa thupi.
Umboni wazachipatala womwe ukuthandizira kugwiritsa ntchito semaglutide kwa mankhwala onenepa
Kutha Kwapang'onopang'ono kwa matenda a kunenepa kwambiri omwe amaphunziridwa kwambiri m'mayesero azachipatala, pogwiritsa ntchito umboni wokakamiza kugwiritsira ntchito ngati njira yotetezeka komanso yothandiza pakuwongolera thupi.
Mu mayeso amodzi a chidwi, omwe amadziwika kuti ndi matenda (Semaglitiside mwamphamvu mwa anthu omwe ali ndi kunenepa kwambiri) dongosolo, ofufuza adawona kuti maphunziro a semagulic omwe ali ndi ophunzira oposa 4,500. Zotsatira zake zinali zovuta: Ophunzira amalandila jakisoni wa semaglutide adazindikira kwambiri kuwonjezeka kwakukulu poyerekeza ndi omwe amalandila ma placebox index komanso m'chiuno.
Kuphatikiza apo, mankhwala osokoneza bongo amagwirizanitsidwa ndi kusintha kwamitundu yosiyanasiyana, kuphatikizapo matenda oopsa, dyslupidemia, ndi mtundu wa shuga wa 2. Zopeza izi zadzetsa kuphatikizira kwa Semaglutide ku malangizo azachipatala azachipatala, monga omwe amafalitsidwa ndi American shuga Machesi ndi European Phunziro la shuga.
Anthu ambiri amafunafuna mayankho ogwira mtima komanso osakhazikika pakuchepetsa thupi, amakonzedwa kuti atchule gawo la mankhwala osokoneza bongo, omwe amapereka zotsatira za chipatala cha nthawi yayitali.
Mapeto
Ma jakisoni a semaglutide atuluka ngati njira yosinthira anthu omwe akuvutika ndi kunenepa kwambiri, kupereka njira yabwino kwambiri komanso yosavuta kwa kuchepa kwa thupi komanso kuwongolera kwa chakudya. Pokakamiza umboni wa chipatala kuchirikiza kugwiritsa ntchito kwake komanso mbiri yabwino, Semagilitide imayimira patsogolo ntchito yabwino polimbana ndi kunenepa kwambiri komanso zoopsa zawo.
Monga akatswiri azaumoyo komanso anthu ambiri chimodzimodzi amazindikira kuthekera kwa semagutide kuti asinthe miyoyo, ndikofunikira kupitiliza kufufuza zabwino zake ndikugwiritsa ntchito ntchito yake muzochita zachipatala. Pogwiriritsa mphamvu ya jamuglide, titha kupatsa mphamvu anthu kuti azitha kuwononga thupi, kukonza thanzi lawo lonse, ndikusintha kwa nkhondo yolimbana ndi kunenepa.
