Kuhambo ukuya ekufezekiseni ubunzima bempilo, abantu abaninzi bazifumana bekhangela ukhetho olungaphaya kokutya kunye nokuzivocavoca. Ukuqhubela phambili kwesayensi yezonyango kuzisa amayeza anokunceda Ukuphulukana nobunzima , ukubonelela ngethemba elitsha kwabo basokolayo. Amayeza amabini anje, i-Wogovy kunye neSaxenda, baye bafumana ingqalelo ngokusebenza kwabo. Ukuqonda ukungafani kwabo kunye nezibonelelo kubalulekile ekwenzeni ukhetho olunolwazi.
Omabini amayeza avunyiwe yi-FDA kwaye amiselwe ukuxhasa ukuthotyelwa kwesisindo kubantu abadala abakutyeba kakhulu okanye abethatyambe kakhulu iimeko zempilo ezinxulumene nobunzima. Njengomdla kolu nyango ukhula, kunjalo ke kufuneka ukuqonda ukuba isebenza njani iyeza ngalinye kwaye kunokuba lilungele ngakumbi iimfuno.
I-Wogonda kwaye i-saxenda linamayeza amabini angenamatshiwo enzelwe ukunceda ekulahleni ubunzima, nganye ineepropathi ezizodwa kunye neendlela, kunye nokukhetha ilungelo lezempilo kunye neenjongo ezithile zokunciphisa umzimba.
Ukuqonda i-Wogovy kunye ne-saxenda
I-Wogovvy (semaglutide) kunye ne-saxenda (liraglutide) yeklasi yamatsha asaziwa njenge-GLP-1 ReadPortors. Balinganisa i-hormone glucagon-njenge-peptde-1, edlala indima kumgaqo wokutya kunye nokutya ukutya. Ngaphandle kokufana kwazo, la mayeza aneminyaka eyahlukileyo ekwenzeni kwabo, amachaphaza kunye nolawulo lwezandla zolawulo.
I-Wogovv iqulethe i-Semaglutide, i-computer iphuhlisiwe ukuba ithathe i-Type 2 yeswekile phantsi kwegama le-Ozempic. I-Wogovy inyikima ngokukodwa ukulawulwa kwesisindo kwaye ilawulwa kanye ngeveki nganye ngenaliti. Ukuvunywa kwayo kokuphulukana nobunzima kusekwe kwizilingo zeklinikhi ebonisa ukunciphisa ubunzima bomzimba kubathathi-nxaxheba.
Kwelinye icala, i-saxenda iqulethe i-liraglutide, ekwasetyenziselwa ukulawulwa kwe-glycemic kwiswekile phantsi kwegama le-victoza. Ngeenjongo zokulahleka kobunzima, i-SAXEnda imiselwe kumthamo ophezulu kwaye iqhutywa yonke imihla ngenaliti. I-Saxenda yavunywa kwangaphambi kokuba i-Wogov kwaye isetyenziswe ngokubanzi iminyaka eliqela.
Umahluko ophambili phakathi kwamayeza amabini yishedyuli yabo ye-dosage. Inaliti ye-Wogovvevanyene-veki nganye inokubangela ukuba kube lula xa kuthelekiswa nenaliti yemihla ngemihla efunekayo kwi-SAXEnda. Lo mahluko unokubangela ukubambelela kwirejimeni yonyango kunye nolwaneliseko lwesigulana.
Ukuqonda ukuba umahluko osisiseko ubalulekile xa ucinga la mayeza. Izinto ezifana ne-dosing rhoqo, iqhelene nokuzithoba, kwaye indlela yokuphila inokuba nefuthe ekukhetheni phakathi kwe-Wogov kunye ne-saxenda.
Iindlela zendlela abasebenza ngayo?
Ngelixa amayeza omabini amayeza yi-GLP-1 Agnorists, ayahluka kancinane kwimo yayo yeemolekyuli kunye nendlela echaphazela ngayo umzimba. I-GLP-1 yi-hormone ekhuthaza ukhuseleko lwe-insulin, ithintele ukukhutshwa kwe-glucagon, icothisa i-gestric ekhuphayo, kwaye inyuse i-SATAT-yonke igalelo ekunciphiseni ubunzima.
I-Wogovvy (semaglutide) inesiqingatha sexesha elide-ubomi be-saxenda (i-liraglutide), ivumela ukuba ilawulwe kube kanye ngeveki. I-Semaglutide Binds kwi-GLP-1 Reftor enefuthe eliphezulu, ekhokelela kwimpembelelo ethe kutyala kwaye inciphise ukutya okutyayo.
I-Saxenda isebenza ngokufanayo kodwa ifuna ulawulo lwemihla ngemihla ngenxa yexesha elifutshane elifutshane lesenzo. I-Liraglutide iyacothisa i-Gastric Eckting kwaye iphucule i-Sature, kodwa iziphumo zinokugcinwa kancinci xa kuthelekiswa ne-semaglutide.
Omabini amayeza hayi kuphela inkxaso yokulahleka kwesisindo kodwa unefuthe elihle kwimiba yomngcipheko we-Cardiovascular. Banokuphucula uxinzelelo lwegazi, amanqanaba e-cholesterol, kunye nolawulo lwe-glycemic, oluyingenelo ikakhulu kubantu abaneemeko zempilo ezinxulumene noko.
Ukuqonda ukuba amayeza asebenza njani ekuncedeni izigulana kunye nababoneleli bezempilo benze izigqibo ezizizo. Umahluko we-pharmacokinetic phakathi kweSemaglutide kunye ne-liraglutide banokuphembelela ukusebenza kwabo kunye nokufaneleka kwabo baguli.
Ukusebenza kakuhle kunye neziphumo zokulahleka kobunzima
Uvavanyo lweklinikhi lubonakalisile ukuba zombini i-wegov kunye ne-saxenda ziyasebenza Ukuphulukana nobunzima xa kudityaniswa ungenelelo lwendlela yokuphila njengokutya kunye nokuzilolonga. Nangona kunjalo, kukho umahluko ongabonakaliyo kwinani lokuphulukana nobunzima obubonwa ngamayeza nganye.
Izifundo zibonise ukuba abaguli basebenzisa i-Wogovy banokufumana ilahleko enkulu yokusebenza xa kuthelekiswa neSaxenda. In clinical trials, participants taking Wegovy lost an average of around 15% of their body weight over 68 weeks, while those taking Saxenda lost approximately 5% to 10% over 56 weeks.
Ukusebenza okukhulu kwe-Wogovy kunokubangelwa kukuzinza kwayo okuphezulu kunye nesenzo sexesha elide. Ukuphulukana nobunzima obukhulu obufunyenwe i-Wogovy ibiyinto ephambili ekuthandeni okukhulayo phakathi kwabaguli abafuna ukunciphisa ubunzima obufuna ubunzima obukhulu.
Nangona kunjalo, iziphumo zomntu ngamnye zinokwahluka ngokusekwe kwizinto ezininzi, kubandakanya ukubambelela kwirejimeni ye-Preser, iinguqu zendlela yokuphila, kunye neemeko zempilo zobuqu. Kubalulekile ukuba abaguli babe nokulindela okuqinisekileyo kwaye basebenze ngokusondeleyo nabanikezeli babo bezempilo.
Ekugqibeleni, ngelixa i-wegovy inokubonelela ngokuphulukana nobunzima obufanelekileyo, ingakumbi kwabo banokukhetha ukutyholwa kwemihla ngemihla okanye baqwalasele ukhetho olukhethekileyo lwezempilo olunokwenza ukuba kuqwalaselwe ngcono.
Iziphumo ebezingalindelekanga kunye nokuqwalaselwa kukhuseleko
Njengawo onke amayeza, i-Wogovy kunye ne-saxenda beza neziphumo ebezingalindelekanga ezinokubakho izigulana. Iziphumo eziqhelekileyo zomayeza zibandakanya iimpawu ze-gestrointentinal ezifana ne-nausea, ukugabha, isifo sohudo, isisu, kunye nentlungu yesisu.
Iziphumo ebezingalindelekanga zihlala zibhengezwe ngakumbi ekuqaleni konyango kwaye zinokuthotyelwa njengoko umzimba uguquka kumayeza. Ukunyuka kwethanga lokunyuka kancinci njengoko kumiselwe ngumboneleli wezempilo onokunceda ukunciphisa ezi ziphumo.
Iziphumo ezibi kakhulu zinqabile kodwa zinokubandakanya i-pancrearitis, isifo se-gullbladder, kunye neengxaki zezintso. Omabini amayeza aphethe isilumkiso malunga nomngcipheko onokubakho wemingcipheko ye-thyroid c-iseke kwizifundo ezikwiintonga, nangona oku akuqinisekiswa ebantwini.
Izigulana ezinembali yobuqu okanye yentsapho yeentlobo ezithile zomhlaza omhlaza okanye ze-endocrine ye-neoplassia ye-neoplassia Kubalulekile ukuxoxa ngayo kwimbali yezonyango kunye nomnikezeli wokhathalelo lwempilo ngaphambi kokuqala unyango.
Ukubeka iliso kwingcali yezempilo kubalulekile ukuqinisekisa ukusetyenziswa ngokukhuselekileyo kula mayeza. Ukulandela rhoqo kunokunceda ukulawula nayiphi na kweziphumo ezibi kwaye kulungiswe unyango njengoko kufuneka.
Ukwenza ukhetho olufanelekileyo: Igovy okanye i-saxenda?
Ukukhetha phakathi kwe-Wogov kunye ne-saxenda kubandakanya ukuthathela ingqalelo izinto ezininzi, kubandakanya neziphumo ezisebenzayo, iziphumo ebezingalindelekanga, kunye neemeko zempilo.
I-Wogovy inokuba lolona khetho lukhethileyo kwabo bafuna ukulahleka okukhulu kwenqanaba lokuqhekeka kwakanye. Impembelelo yayo ebalulekileyo ekunciphiseni kwesiqhelo inokukhuthaza abaguli abazabalaze nolunye ungenelelo.
I-Saxenda inokuba ilungele abantu abathanda ukwenziwa kwemihla ngemihla okanye abanokuthi baphendule ngcono kwi-liraglutide ngenxa yezinto zempilo. Ineprofayili yokhuseleko esekwe kakuhle ukusuka kwiminyaka yokusetyenziswa.
Ixabiso kunye ne-inshurensi yokugubungela inokuba nefuthe kwisigqibo. Omabini amayeza anokubiza kakhulu, kwaye izicwangciso zeinshurensi zinokuba nemigaqo-nkqubo eyahlukeneyo yokugubungela. Izigulana kufuneka zinxibelelane nabanikezeli beinshurensi zabo kwaye bafune iinkqubo zoncedo zoguli xa kufuneka.
Ekugqibeleni, isigqibo kufuneka senziwe ngokusebenzisana nomboneleli wezempilo onokuthi ahlole imbali yezonyango, iinjongo zokunciphisa umzimba, kunye nezinto azithandayo ukucebisa amayeza afanelekileyo.
Ukuqukumbela
Ukuqukumbela, i-Wogovy kunye ne-saxenda zibonelela ngeendlela ezifanelekileyo zonyango zokunciphisa umzimba, nganye ineengenelo zayo. I-Wogovy's Ection Ection kunye ne-dosing yeveki yenza ukhetho olukhawulezileyo lwabantu abaninzi, ngelixa i-saxenda esekwe kwaye irejimeni yemihla ngemihla inokulungela abanye.
Ukuqonda umahluko phakathi kwala mayeza kubalulekile ukuba abaguli baqalisa uhambo lwabo lokunciphisa umzimba. Ngokujonga izinto ezifana nempumelelo, ezibalulekileyo, ukhetho lokwenza izinto, kunye neemeko zempilo, abantu banokusebenza nababoneleli bezempilo ukuze bakhethe ukhetho olufanelekileyo kwiimfuno zabo ezifanelekileyo.
Ukulahleka kwesisindo kuhambo lobuqu nolusoloko lucelomngeni. Ngokufumaneka kwamayeza anjenge-Wogovy kunye ne-Saxenda, zininzi izixhobo kunangaphambili ukuxhasa abantu ekufezekiseni iinjongo zabo zempilo. Unxibelelwano oluvulekileyo kunye neengcali zempilo kunye nokuzibophelela kwiinguqu zendlela yokuphila zizinto eziphambili zempumelelo.
FAQ
Q: Ndingayitshintsha ukusuka kwi-saxenda ukuya kwi-Wogoavy ukuba andiboni iziphumo ezifunwayo?
A: Ewe, kodwa naluphi na utshintsho kunyango kufuneka lwenziwe phantsi kwesikhokelo soMboneleli wezeMpilo.
Q: Ngaba i-wegovy kunye ne-saxenda zigutyungelwe yi-inshurensi?
A: Ukugubungela kuyahluka ngesicwangciso seinshurensi; Kuya kufuneka ujonge ngomboneleli wakho ukuze uqonde izibonelelo zakho.
Q: Ngaba kufuneka ndilandele ukutya okhethekileyo ngelixa ndithatha la mayeza?
A: Ukutya okutyayo-calorie kunye nokwandiswa komzimba kuyacetyiswa ukonyusa ukusebenza kwamayeza.
Q: Ndingahlala ixesha elingakanani kwi-wegovy okanye i-saxenda?
A: Ixesha lonyango kufuneka ligqitywe ngumboneleli wakho wezempilo esekwe kwinkqubela phambili yomzimba kunye nemeko yezempilo.
Q: Kwenzeka ntoni ukuba ndiyalikhumbula idosi yamayeza am?
A: Landela imiyalelo enikezwe nguMboneleli wakho wezeMpilo okanye isikhokelo serekhodi; Nxibelelana nomnikezeli wakho ukuba awuqinisekanga.
Q: Kuthekani ukuba andinguye ongalunganga kwi-Wogovy (semaglutide)?
A: Inene, ezinye iiklinikhi zixele iimeko zezigulana ezihlangabezana nezixhobo zokuphendula kwe-semaglutide. Ukuba awukhalimela ukuya kwi-semaglutide, unokujonga i-Otaty Fit-X njengenye indlela. I-Ottaly Fat-X isebenzisa i-Acety HexApeptide-39, esebenza ngokwahlukileyo kwi-GLP-1 agonists kodwa ibonakalisile imiphumo ethembekileyo yolawulo lomdla kunye nolawulo lobunzima. Uninzi lwabathengi bethu babelane ngaloo nto ngelixa bengengalunganga ukuya kwi-semaglutide, bafumana iziphumo ezigqwesileyo kunye ne-Otely Fit-x ngaphandle kokuphendula ngendlela engeyiyo. Kwizigulana ezinokuthi zinganyamezeli i-semaglutide, ostely fat-x inikezela ukhetho olukhethekileyo nolusebenzayo.
Q: I-Wogovy kunye ne-saxenda zixabisa kakhulu. Ngaba zikho ezinye iindlela ezifikelelekayo?
A: Ukuba ufuna indlela esebenzayo ngakumbi kwinkxaso yolawulo lwesisindo, i-Otely Fit-X kufuneka iqwalaselwe. Xa kuthelekiswa ne-GLP-1 agonists, ostely fat-x ibonelela ngexabiso elifikelelekayo ngakumbi kwaye isetyenziswe ngokubanzi kwiimarike zehlabathi, ngakumbi e-Europe, apho ifumene ingxelo entle kubasebenzisi. I-Otelay Fat-X yenza kakuhle ekuxhaseni ulawulo lwenqanaba lenqanaba, esenza ukhetho olufanelekileyo kwabo baneengxaki zohlahlo-lwabiwo mali abasafuna inkxaso yobunzima obusebenzayo. Ukuba unomdla, zive ukhululekile ukuba Nxibelelana nathi ukuze ufunde ngakumbi malunga nokuthenga ukhetho kunye namalungiselelo afanelekileyo okuhambisa.
