Iyini I-Lidocaine-Infused Dermal Filler Futhi Kungani Iba Yizinga Lomtholampilo

Amathrendi Okuthengwa Kwehlabathi Kuma-Aesthetic Medicine Dlulisela kuma-L idocaine Fillers , Ukuba Izinto Ezisetshenziswayo Zomtholampilo Ezivamile.

Imboni yemithi yobuhle yomhlaba wonke engenelele kancane ibone inguquko ebucayi kule minyaka eyishumi edlule: izigcwalisi zendabuko ze-hyaluronic acid ngaphandle kwama-ejenti okubulala izinzwa ezifakiwe ziyakhishwa kancane kancane ohlwini lwamagama olujwayelekile lwasemtholampilo. Imikhiqizo ye-hyaluronic acid ene-lidocaine manje imele ngaphezu kwama-62% wesamba esisetshenziswa isigcwalisi ezimakethe kulo lonke elaseYurophu, eMelika, eMpumalanga Ephakathi naseNingizimu-mpumalanga ye-Asia. Emitholampilo yobuhle, abathengisi abakhulu nabasabalalisi besifunda abakhethekile, ukufakwa kobufakazi bomtholampilo 'ama-dermal fillers angenabuhlungu ' kuphothifoliyo yomkhiqizo akuseyona inketho kodwa isibalulekile esibalulekile ukuze sihambisane nemikhuba yamanje yokusetshenziswa kweziguli zobuhle kanye nokuthuthukisa ukusebenza kahle.

Njengoba sinesipiliyoni seminyaka engama-25 ekuhwebeni kwamazwe omhlaba kwezithako zokuhlobisa zezokwelapha, ezisatshalaliswa emazweni angaphezu kuka-120 emhlabeni jikelele, senze ngempumelelo ukwakheka ngokwezifiso kwemikhiqizo yobuhle yasendaweni engaphezu kuka-580 phesheya. Kusukela enanini elikhulu lempendulo esiyitholayo kubasebenzisi bethu bokugcina basemtholampilo, singabonisa ngokucacile izinzuzo zezezimali ezivela ekuphindaphindweni kwemikhiqizo. Isibonelo, e-Dubai, umtholampilo wobuhle obuphakathi nendawo washintsha ama-80% ohlu lwawo lokugcwalisa nge Ama-HA fillers ane-lidocaine engxenyeni yokuqala ka-2025. Ngemva kwezinyanga eziyisithupha, kwaba nokwenyuka kwe-41% kwezinga lokubuyela ezigulini ezintsha kanye nokunciphisa ngo-28% ezindlekweni ezisetshenziswayo ezihambisanayo zama-anesthetics asetshenziswa ngaphambi kwenqubo. Lezi zibalo zenzuzo yomhlaba wangempela yingakho izigcwalisi ezithuthukisiwe ze-lidocaine zisheshe zaba indinganiso esetshenziswayo ekusebenzeni komtholampilo emhlabeni jikelele. Lesi sihloko sihlukanisa lesi sihloko sibe izingxenye ezinhlanu ezibalulekile - izimiso zokubunjwa, inani lezentengiselwano emtholampilo, ukuhlukaniswa komugqa womkhiqizo, ukuhambisana nokulawula kanye nokubambisana kwelebula ye-OEM/yangasese - ukunikeza abathengi bomhlaba wonke ulwazi oludingekayo ukuze benze isinqumo esinolwazi nesisekelwe kudatha ekuthengeni okuningi.

I-Core Scientific Principle: I-R&D rationale yefomula engenabuhlungu

Ukuthola ukuthi kungani ama-dermal fillers ane-lidocaine engcono kune 'yakudala', kufanele siphendukele ezincwadini zomhlaba zedermatological kanye nezidingo zokwakhiwa kwezidakamizwa ezamukelwa izinhlangano zezitifiketi ze-CE neziphathimandla ezilawulayo eYurophu naseMelika. Ukugxila okuphephile kwalesi sengezo kungu-0.3% we-lidocaine, okuyindinganiso yezimboni, futhi kuye kwaqinisekiswa izivivinyo zomtholampilo ezisezikhungweni eziningi ukuthi zisebenze kahle ekudambiseni ubuhlungu ngaphandle kokuguqula izakhiwo ze-physicochemical zejeli ye-hyaluronic acid noma ukwandisa izehlakalo zokungezwani komzimba ezigulini.

I-Hyaluronic acid iyingxenye yesikhumba somzimba womuntu. Kushintshwa umthamo wezicubu ezithambile ngokubamba amanzi aphakathi kwezicubu. Isetshenziselwa ukwenza bushelelezi imibimbi emile, ukulungisa kabusha ukubukeka kobuso njengebhuloho lekhala, umugqa womhlathi, izihlathi ze-apula kanye nesilevu, njll. I-Lidocaine exutshwe ngokulinganayo kujeli ingavimba ukudluliswa kwezimpawu zezinzwa kusicubu esingaphansi kwe-subcutaneous imizuzu emi-3 kuya kwemi-5 ngemuva komjovo ongqimbeni olungaphansi kwesikhumba. Lokhu kuxazulula ubuhlungu obubangelwa izinqubo zokugcwalisa zendabuko ezifana nokubhoboza inaliti ngesikhumba kanye nomjovo we- layered. Ngokungafani nemodi yangaphambilini yokusebenza yokugcoba kuphela ngaphambi kwenqubo, isixazululo esixutshwe ngaphambili sokubulala izinzwa singalandela i-hyaluronic acid ukuze isakaze ungqimba ngongqimba kuya ezingqimbeni ezihlukene zesikhumba, ithuthukise ngokugcwele umjovo wokunethezeka wesiguli kuyo yonke inqubo.

Ithimba lethu lefektri ye-R&D yozakwethu selizinikele ekwenziweni kwe-hyaluronic acid exhumene kakhulu iminyaka engaphezu kwengu-20, futhi lilawula ngokuqinile lonke uchungechunge lokuhlinzekwa kwempahla eluhlaza. Isisekelo se-hyaluronic acid siyimpushana esezingeni eliphezulu yokuhlanzeka kwezemithi, izindleko zokuthenga yi-$ 45,000 ngekhilogremu ngayinye. Ikhiqizwa egumbini lokuhlanza eliyinyumba le-GMP Class 100 ngenqubo yokuhlanza i-osmosis enezinyathelo ezingama-27 kusetshenziswa amanzi ukuze umjovo. Le nqubo isusa noma yikuphi ukuvuvukala kwangemva kokuhlinzwa okubangelwa ukungcola futhi iqinisekisa ukusatshalaliswa okufanayo kwe-lidocaine ngaphakathi kwe-monophasic noma i-biphasic hyaluronic acid gel matrix. Izifundo zemitholampilo ezigunyaziwe ezifakwe ku-NCBI ziqinisekisa ukuthi ukuba khona kwe-lidocaine ezilinganisweni ezihambisanayo akuthinti izinga lokuxhumanisa, izinga le-metabolic lomzimba kanye nobude besikhathi somphumela wobuhle. Ukwakheka kobuso okujwayelekile okungu-1ml kanye no-2ml kunemiphumela ehlala izinyanga eziyi-9-12, futhi izigcwalisi zomzimba zevolumu engu-10ml no-20ml zinemiphumela ehlala izinyanga eziyi-12–18—ngokuhambisana nempilo ende yemikhiqizo yamazwe ngamazwe ehamba phambili njenge-Restylane ne-Juvéderm.

Izinzuzo Ezine Ezibalulekile Zemitholampilo Nezentengiselwano I-Lidocaine Fillers izoba Izinga Lomkhakha Olandelayo? (Ukuhlaziywa okusuka kumbono womtholampilo kanye nenzuzo yokusabalalisa)

Okuqukethwe okulandelayo kusekelwe emhlabeni wangempela, impendulo eyiqiniso evela emphakathini wethu womhlaba wonke wezikhungo zezokwelapha zobuhle zozakwethu kanye namakhasimende athenga ngobuningi futhi kuhlobene ngokuqondile nokuthuthukisa inzuzo nokuncintisana kwemakethe kwabathengi bethu.

Thuthukisa ngendlela emangalisayo izinga lokuguqulwa kwamakhasimende amasha kanye nezinga lokuthenga eliphindayo

Idatha yocwaningo lwemboni yembula ukuthi ngaphezu kwe-61% yeziguli ezingahle zigweme ukubonisana nokugcwalisa ngenxa yokwesaba ubuhlungu obuhambisana nokujova. Imitholampilo eshintshele ekubeni yizigcwalisi ze-lidocaine yehle ngo-50% esilinganisweni sezinga layo lokuphelelwa amandla kwamakhasimende. Uchungechunge lwaseBrazil lwemitholampilo yobuhle (iklayenti lethu lesikhathi eside) lenyuse izinga lokuguqulwa kwekhasimende elisha ngo-37% phakathi nezinyanga ezintathu zokushintshela ngokuphelele emikhiqizweni yokugcwalisa equkethe i-lidocaine. Ngaphezu kwalokho, u-89% weziguli ezathola ukwelashwa kwe-filler zibuyiselwa ukuzothintana, i-contouring noma ezinye izindlela zokwelapha ukuguga phakathi nezinyanga eziyishumi, okuqinisekisa ukusakazwa kwemali okuthembekile nokuqhubekayo.

Ukwehliswa kwezindleko zokuhlinzeka emtholampilo nezabasebenzi, kanye nokugeleza komsebenzi kwangaphambi kokuhlinzwa okwenziwe lula

Izinqubo zendabuko zokugcwalisa isikhumba sesikhumba zidinga isikhathi sokwelashwa sangaphambi kokwelashwa semizuzu engama-20 kuye kwengama-40 okuvamise ukubandakanya ukusetshenziswa kwezingubo ezivalekile. Lokhu kudla ukhilimu obulala izinzwa kanye nesikhathi sabasebenzi abahlengikazi. Kodwa ngezihlungi ezixutshwe ngaphambilini ne-lidocaine, weqa konke lokho kubalwa futhi ulondoloza u-22% kuya ku-30% wezinto ezisetshenziswayo kanye nomsebenzi ngenqubo ngayinye.' Lokhu kuholela ekongeni okukhulu kokusebenza phakathi nonyaka emitholampilo emikhulu yobuhle eyenza amakhulukhulu ezinqubo zokugcwalisa nsuku zonke.

Ukunciphisa ukusabela okubi ngemva kokuhlinzwa nokunciphisa izingxabano zezokwelapha zobuhle

Ukusetshenziswa ngokweqile kokhilimu obulala izinzwa esikhumbeni kungabangela kalula ukusabela okubi ezigulini ezinesikhumba esibucayi, njengokubomvu, ukulunywa kanye nokuvuvukala okubambezelekile. Ngokwemininingwane yezibalo enikezwe abaxhasi bethu bemitholampilo yaphesheya kwezilwandle, inkampani yethu ibambelele kufomula yobunikazi engaguquki enezithako ezisebenzayo ezingu-0.3% ezivumelana ngokuqinile nezindinganiso zemithamo yezokwelapha emhlabeni wonke, futhi lokhu kubangele ukwehla okukhulu kokungezwani komzimba okubikiwe.

Ukuvumela abasabalalisi ukuthi bahlukanise imikhiqizo yabo futhi benze izimakethe zabo zibe ngokwendawo

Ama-ejenti akhethekile wesifunda kanye nabathengisi bezitolo ngobuningi bangakwazi ukugcina uhla oluphelele lwabaqeqeshwe ngokugcwele, izigcwalisi zebanga lomtholampilo ezihlanganisa uhla oluphelele lwa Imikhiqizo yokugcwalisa i-dermal eqinisekisiwe ye-CE , ukwenza inzuzo ecacile yokuncintisana ngaphezu kwamafayili angafanelekile, asezingeni eliphansi azungeza emakethe njengamanje. Sizuze isabelo semakethe esingaphezu kuka-30% emakethe yasendaweni yezinto ezisetshenziswayo zokugcwalisa izihlungi ezimaphakathi eMpumalanga Ephakathi naseMpumalanga Yurophu ngenxa yozakwethu bethu abathengisa ngama-wholesale abanamalungelo e-ejensi akhethekile ohlu lwethu olugcwele lwezigcwalisi ezifakwe nge-lidocaine.

Izinhlobonhlobo zokugcwalisa i-lidocaine ezihlukaniswa ngokwezimo zokusetshenziswa komtholampilo

Izigcwalisi zethu ezithobela ngokuphelele i-lidocaine ezifakwe ku-dermal ziwela emigqeni emibili emikhulu yomkhiqizo, ehlukaniswa ngomehluko ekugxilweni kwe-hyaluronic acid, ukuminyana okuxhumanisayo kanye nomthamo wokugcwalisa, ohlanganisa lonke uhla lwezidingo zomtholampilo, kusukela ekulungisweni kwemigqa emihle kuya ekuqoshweni nasekukhuliseni ama-contours amathambo:

I-Fine Line Refinement Series (1ml/2ml): I -cross-linking ephansi, i-biphasic hyaluronic acid + 0.3% Lidocaine

Ilungele ukwelapha izinyawo zegwababa, imigqa emihle ye-perioral kanye ne-dear trough kanye nokwandisa izindebe. Ijeli ithambile futhi ingasakazwa kalula futhi ngokulinganayo. Kukhona ukuvuvukala okuncane ngemva kwenqubo. Lolu chungechunge 'lungumkhiqizo wokuhlola' ophambili wemitholampilo yobuhle emincane kuya kosayizi omaphakathi futhi lusebenza ngempumelelo ekuqhubeni ukutholwa nokuzibandakanya kwamakhasimende.

I-Deep Contour Sculpting Series (1ml/2ml): I-hyaluronic acid exhumene kakhulu ne-Lidocaine

Umkhiqizo oyisisekelo wezikhungo zobuhle bezokwelapha ezichwepheshile, wokwelapha ukugoqa okujulile kwe-nasolabial kanye nemigqa yasebunzini, kanye ne-rhinoplasty, i-chin augmentation, i-volumization yethempeli kanye nencazelo yomhlathi. Ijeli inokusekelwa okuhle kwesakhiwo kanye nokumelana nokufuduka, okuyenza ilungele umjovo ojulile we-dermal noma we-supraperiosteal.

Futhi sinikezela ngezihlungi zokuvuselela eziyinhlanganisela ye-PLLA ngenketho yokwenza ngokwezifiso komuntu ngamunye. Ngokuya ngezidingo zomuntu ngamunye, angenziwa nge-lidocaine noma ngaphandle kwayo futhi asebenzise ithuba lokukhuthazwa kokukhiqizwa kwe-collagen yomzimba ukuze alethe imiphumela ehlala isikhathi eside yokuhlanganisa, isikhathi esingaphezu kweminyaka emibili. Lokhu kuwenza abe yinketho efanelekile yamaphakheji okwelapha okulwa nokuguga asezingeni eliphezulu.

Ukubambisana kwelayisensi yokugcwalisa ye-Lidocaine OEM kanye nesixazululo sokwenza ngokwezifiso ifomula ye-Filler Iqondiswe kubakhiqizi bomkhiqizo bomhlaba wonke kanye nabathengi bamalebula azimele

Ngokungafani nabanye abahlinzeki bezinto zokusetshenziswa zokugcwalisa, sineminyaka engama-25 yesipiliyoni embonini, umtapo wolwazi onamafomula afakazelwe angaphezu kwenkulungwane, kanye nethimba labeluleki abangochwepheshe, okuhlanganisa nodokotela besikhumba abaqinisekisiwe abavela eYurophu, e-US, eNingizimu Korea nase-UAE, ukuhlinzeka ngezinsizakalo eziphelele zokwenza ilebula yangasese ezindaweni ezine ezibalulekile:

Ukulungiswa Kokwakhiwa: Silungisa inani le-lidocaine phakathi kwebanga eliphephile ngokwezempilo futhi sengeza izithako ezifana ne-collagen, i-PDRN, i-PLLA uma siyicela. Ukugxila kwe-hyaluronic acid kushintsheka kalula phakathi kuka-20mg/ml kanye no-25mg/ml, kuyilapho i-viscosity yejeli nokusekelwa kwesakhiwo kuhambisana nokuthandwa kobuhle bemakethe ngayinye.

Ukwenza Ngokwezifiso Ukupakisha: Amalogo aqondene nekhasimende asetshenziswa kumasirinji, amabhokisi angaphandle kanye nezitsha. Amasirinji afika ngosayizi ojwayelekile we-1ml, 2ml, 10ml kanye no-20ml kanye nezinaliti kusuka ku-26G kuya ku-30G ezindaweni ezihlukene zokujova.

Idizayini Yomkhiqizo: Abaklami abayisithupha abanolwazi olunzulu kumazinga wobuhle bemakethe yomhlaba wonke yezobuhlengikazi bahlinzeka ngedizayini yamahhala yesakhiwo sokupakisha kumakhasimende anelebula yangasese.

Ukukhiqiza Okunokwethenjelwa : Uma amafomula akho nokupakishwa sekuqediwe, ama-oda amalebula ayimfihlo ajwayelekile aqedwa emavikini angu-2-3. Siyaqinisekisa ukuthi sizoletha ama-oda amakhulu emhlabeni wonke ngesikhathi futhi sibe namandla okukhiqiza nyanga zonke angama-500,000 amasirinji.

Sethule ngempumelelo imikhiqizo yelebula yangasese yemikhiqizo yasendaweni yezokwelapha engaphezu kuka-580 emazwekazini amahlanu kuze kube manje, futhi sisize abaningi bozakwethu bethu ukuba babe abahlinzeki abahamba phambili bokugcwalisa i-dermal ezifundeni zabo.

Isiphetho: Sebenza nomphakeli ofanele othobela i-lidocaine filler ukuze uthathe ithuba lokukhula kwemakethe yendawo yezokwelapha.

Ngokomkhuba womhlaba wonke we-aesthetics yezokwelapha, isabelo semakethe sokugcwalisa i-hyaluronic acid engenabuhlungu nge-lidocaine sizokhula kancane kancane eminyakeni emi-3-5 ezayo. Sezilungele ukufaka esikhundleni ngokuphelele izigcwalisi zendabuko ngaphandle kwama-ejenti okubulala izinzwa futhi zibe izinto ezisetshenziswayo ezijwayelekile ezinqubweni zobuhle ezingangeneleli kancane. Amandla abangela lolu shintsho ukwanda kwesidingo sesiguli sokuthola ukwelashwa okunethezekile kanye nesifiso somkhakha sokuthola inzuzo ephezulu.

Uma unguxhaxha lwezibhedlela zokuhlinzwa zepulasitiki noma umtholampilo owodwa wezinga eliphezulu noma ungumsabalalisi ofuna ukuvikela amalungelo endawo akhethekile, wengeza athobelayo, afakazelwe ngokomtholampilo. ama-lidocaine fillers kuphothifoliyo yomkhiqizo wakho kuwumnyakazo wamasu wokukhula kwemali engenayo yesikhathi eside. Amaqembu okuthengisa nawokusebenza ayatholakala ukuze anikeze amanani entengo amaningi, amasampuli amahhala kanye nokuhlelwa kwelebula yangasese yangokwezifiso, uma efunwa. Ungasithinta ngewebhusayithi yethu esemthethweni ukuze uthole ikhathalogi yomkhiqizo ogcwele kanye nezifundo zezibonelo ezivela ezinhlelweni zomtholampilo zomhlaba wonke.