In today's medical aesthetics market, the treatment of acne scars is undergoing a paradigm shift from short-term filling to long-term regeneration. Clinical evidence shows that mesotherapy based on PDRN can provide better long-term effects than traditional hyaluronic acid filling. This report provides a complete solution evaluation framework for medical aesthetic institutions through comparative analysis, clinical data and operation guidelines.
The Differences In The Mechanism Of Action Between PDRN Mesotherapy And Traditional Hyaluronic acid Fillers
The following is a comparison of the core differences between PDRN Mesotherapy Injection and traditional hyaluronic acid HA filling products in terms of mechanism of action, persistence of therapeutic effect and overall effect.
| Comparison Dimension | Hyaluronic Acid Fillers | PDRN Mesotherapy |
| Core Mechanism Of Action | Physical filling. It mainly relies on its powerful hydration capacity to temporarily increase the volume of the concave area by absorbing water, providing an immediate visual leveling effect. | Biological regeneration. As a cellular signaling molecule, it achieves structural repair by activating the skin's own repair mechanisms (such as activating the adenosine A2A receptor), stimulating fibroblasts to synthesize new collagen, elastin and hyaluronic acid. |
| Persistence | The effect is not permanent. The injected HA gel will be metabolized and absorbed by the human body over time. The clinical effect usually lasts for 6 to 12 months, after which repeated treatment is required to maintain the effect. | The effect is long-lasting. The autologous collagen it induces to regenerate can exist for a long time. Studies show that 12 months after the end of treatment, the improvement in skin texture and scar depth can still be maintained at over 70%, providing a more lasting solution. |
| Comprehensive Improvement Effect | The improvement dimensions are relatively single. It mainly targets improving the depth of scar depression, but has limited effect on enhancing the color, texture and overall skin health of scars. | Provide multi-dimensional improvements. In addition to effectively reducing the depth of scars, it can also: 1. Improve the color of scars and the overall luster of the skin. 2. Optimize skin texture by promoting the orderly regeneration of collagen, making the skin smoother and tighter. 3. It has anti-inflammatory effects, which help improve the chronic inflammatory state in the scar area and create a favorable environment for repair. |
| Summary | "Fill" the space. It is a passive compensation for the defect result, does not change the biological basis of the scar, and the effect disappears along with the disappearance of the filler. | "Regenerate" tissue. It is an active activation of the repair ability, rebuilding a healthy skin structure from the root, and the effect comes from the continuous new tissue of the self. |
Clinical Effects Of PDRN: Data And Case Analysis
PDRN Mesotherapy Injection has demonstrated quantifiable, multi-dimensional and long-lasting clinical improvement effects in the treatment of acne scars.
A prospective study on patients with moderate to severe acne scars confirmed that after completing a standard course once a month for three consecutive months, through high-resolution three-dimensional skin imaging analysis, the average scar depth of the patients was significantly reduced by 62.3%, and the skin surface roughness was decreased by 57.8%. More importantly, this improvement is characterized by sustainability. Data shows that within six months after the treatment ended, the overall recovery effect of the skin continued to progress, with an additional 18.2% increase in the improvement rate.
Product Solutions, High-Standard Requirements For Professional-Grade PDRN Products
The Response To PDRN Mesotherapy Varies For Different Types Of Scars.
●The improvement of rolling and carriage type scars is the most significant, with an average objective improvement rate of up to 71.4%. However, ice cone scars usually require a more intensive treatment plan (such as increasing the treatment frequency or combining with auxiliary technologies like microneedles). Even so, after optimizing the plan, an average effective improvement of 46.7% can still be achieved.
●At the level of patients' subjective feelings, satisfaction surveys show that as high as 92% of those receiving treatment are willing to recommend this therapy to others. The core reasons for this are concentrated on "natural effect presentation" (87%) and "no need for frequent repeated treatment" (83%).
●It precisely responds to the market mesotherapy for skin rejuvenation demand, that is, the deep-seated demand of consumers for regenerative therapies that can bring fundamental and long-lasting skin rejuvenation.
In the face of a wide variety of PDRN products on the market, high-quality PDRN products not only ensure the concentration of their components but also demonstrate professional standards in terms of raw material sources, production processes, and formula designs. Professionals should evaluate products from the following core dimensions:
●Ingredients and Concentration: The product should clearly indicate the exact source of PDRN and the clinically effective concentration (for example, 6.525mg of PDRN sodium salt per 3ml solution). This is the basis for ensuring its biological activity and clinical effectiveness.
●Production process: Production must be carried out in a 100-level clean workshop that complies with the International Good Manufacturing Practice (GMP) for pharmaceuticals to eliminate the risk of contamination. Advanced aseptic filling and freeze-drying technologies can maintain the stability of components to the greatest extent.
●Packaging system: Medical-grade borosilicate glass ampoules and medical-grade silicone stoppers should be adopted to ensure the aseptic state to the greatest extent and prevent the degradation of active ingredients.
Safety Operation Guidelines And Standardized Procedures
Strictly adhering to the standardized operation procedures based on evidence-based medicine is the key to ensuring the safety and reproducibility of the therapeutic effect of PDRN treatment. According to the updated mesotherapy safety guidelines 2025, a complete set of treatments should cover the following core aspects:
●Before treatment: A comprehensive skin assessment and patient screening must be conducted to clearly define contraindications (such as active infection, pregnancy).
●During the operation: In a sterile environment, use a disposable sterile needle to precisely inject the product into the middle layer of the dermis (recommended depth: 0.5-1.0mm). It is recommended to use dot matrix or micro-multi-point technology. The single-point injection volume is usually no more than 0.05ml.
●Post-care guidelines for mesotherapy clients: Within 24 hours after treatment, patients should avoid high-temperature environments, strenuous exercise and direct sunlight, and use medical repair products as directed by the doctor to promote recovery and consolidate the therapeutic effect. Establishing a standard follow-up plan is crucial for evaluating the effect and formulating personalized maintenance plans.
The Complete Path For Institutions To Implement PDRN Mesotherapy
For medical aesthetics institutions, successfully introducing and promoting PDRN therapy requires a systematic approach.
●Product and partner selection: Choose professional suppliers that not only offer high-quality products but also provide clinical training, treatment plan design, and compliance support (such as whether they offer OEM/ODM customization services, clinical training support, etc.).
●Systematic team training: The training should go beyond basic operations and cover the product's mechanism of action, injection strategies for different types of scars, patient expectation management, and handling of adverse reactions.
●Clinical process standardization: Establish a standardized process from the initial consultation, treatment records to regular follow-ups. Objectively record the imaging data of mesotherapy for acne scars before and after for effect evaluation and case accumulation.
●Value-based professional communication: Marketing promotion should focus on the scientific principles of the therapy and genuine, verifiable clinical effects, and build trust through professional education and transparent communication.
Conclusion
PDRN Mesotherapy Injection, through its unique tissue regeneration mechanism, offers an advanced solution for acne scar treatment, ranging from "surface filling" to "root repair".
Accurate clinical data, strict product and operation standards, as well as systematically implementable clinical pathways jointly constitute its core value in the professional medical aesthetics market, and it is expected to meet the market demand for mesotherapy for skin rejuvenation.
Leading the market impact of new mesotherapy therapies, namely the novel mesotherapy, has had a profound influence in clinical practice and the market landscape.
