Plasmin inhibitor; ihagarika inzira ya plasminogen - plasmin ihuza UV ihura ningirabuzimafatizo zuruhu na melanocyte
Uburyo ikoreshwa
Capsules yo mu kanwa cyangwa lozenges, amavuta yo kwisiga; IV ibitonyanga birakunzwe ariko bitemewe; rimwe na rimwe byongewe kuri intotheral mesotherapy cocktail
Serumu yibanze; mesotherapie intradermal cyangwa microneedling ya pigment; hejuru-ya IV infusion ni itandukanye, ikoreshwa rya sisitemu
Glutathione ni antioxydants isanzwe iboneka imbere muri selile zose. Isubiramo risobanura ingaruka zacyo nkizituruka ku kubuza tyrosinase mu buryo butaziguye kandi butaziguye no guhindura synthesis ya melanin yerekeza kuri pigment yoroheje (Sonthalia et al., 2016). Mu bushakashatsi bugenzurwa, ariko, ingaruka ni nto. Ikigeragezo cyateguwe, gihumye-buhumyi mu bakorerabushake 60 bo muri Tayilande cyerekanye ko mg 500 za glutathione yo mu kanwa buri munsi mu byumweru bine byagabanije indangagaciro za melanin kuruta umwanya wa kibanza kuri bibiri gusa kuri bitandatu (Arjinpathana na Asawanonda). Ubushakashatsi bwakorewe kuri buccal lozenge ku bagore 30 bo muri Filipine na bo bavuze ko hagabanutse indangagaciro za melanin, ariko ntizari zifite itsinda rya placebo (Handog et al., 2016).
Ibimenyetso bya glutathione yimitsi iracyafite intege nke. Ubushakashatsi bwonyine bwagenzuwe na IV bwerekanye ko nta tandukaniro rinini riri hagati ya saline (37.5% vs 18.7% byateye imbere, p = 0.054), iterambere ryaragabanutse mu mezi atandatu, kandi abitabiriye amahugurwa benshi bakoze ibizamini byumwijima bidasanzwe cyangwa anaphylaxis (Zubair et al., 2016). Isuzuma ryakozwe mu 2024 ryanzuye ko IV glutathione yandujwe no kumurika uruhu kandi ko glutathione 'ishobora gukora cyane nka antioxydeant muri melasma ' (Sarkar et al.). Kubireba abarwayi, reba ibyacu kuyobora uburyo inshinge za glutathione zera zikora.
Vitamine C: Umufatanyabikorwa wa Antioxydeant
Acide ya Ascorbic itesha agaciro radicals yubusa itangwa numucyo UV kandi ikabuza tyrosinase, niyo mpamvu imaze igihe kinini ikoreshwa mugusaza amafoto no hyperpigmentation (Telang, 2013). Intege nke zayo nyamukuru ni ugutanga: vitamine C idahindagurika kandi biragoye kwinjira muri dermis yibitekerezo byingirakamaro, bisobanura inyungu muri mesotherapie na microneedling.
Iyo vitamine C yatewe imbere muri melasma, iba iyifite. Isesengura ryakozwe na 2024 ryakozwe n’ubushakashatsi butanu (abarwayi 127) ryasanze nta tandukanyirizo rishingiye ku mibare ryakozwe mu iterambere rya MASI hagati ya TXA mesotherapy na vitamine C mesotherapie maze basanga bombi bafite umutekano (Liao et al.). Ubushakashatsi bwari buto, ibi rero birasomwa neza nka 'ugereranije namakuru make ' aho kuba gihamya yuburinganire.
Acide Tranexamic: Inzobere ya Melasma
Acide Tranexamic yakozwe nkumuti ugabanya kuva amaraso. Uruhare rwarwo muri pigment ruva muguhagarika ibikorwa bya plasmin, inzira igira uruhare muri UV-iterwa na melanocyte. Mu bushakashatsi bwa mbere bw’imbere, abagore 85 b’Abanyakoreya bakiriye buri cyumweru 4 mg / mL mikorobe zatewe na melasma mu byumweru 12; impuzandengo ya MASI yagabanutse kuva 13.22 igera kuri 7.57 hamwe n'ingaruka nkeya (Lee et al., 2006). Ubwo bushakashatsi ntabwo bwari bufite itsinda rishinzwe kugenzura. Igeragezwa ryakozwe nyuma y’abarwayi 60 ryagaragaje ko 35,72% MASI yateye imbere hamwe na virusi ya TXA na 44.41% hamwe na TXA yatanzwe na microneedling, nta kibazo gikomeye cyabaye (Budamakuntla et al., 2013).
Ibisobanuro birambuye bya protocole, intera intera no gutoranya abarwayi bikubiye mu ngingo yacu yihariye kuri tranexamic aside mesotherapy ya melasma , ntabwo rero tuzabisubiramo hano.
Niki Cyiza? Icyemezo cyo gufata ibyemezo byuruhu
Nta inshinge nimwe nziza yo kwera. Guhitamo neza gukurikira kwisuzumisha:
Melasma
TXA nicyo kintu cyambere mubintu byinshi abahanga mu kuvura dermatologue bageraho, bitangwa imbere cyangwa hamwe na microneedling, hamwe no kurinda izuba rikomeye. Vitamine C mesotherapy nubundi buryo bushyize mu gaciro cyangwa umufatanyabikorwa, urebye ibisubizo byagereranijwe muri meta-gusesengura. Glutathione niyongeweho kubushake, ntabwo igisubizo cyonyine.
Muri rusange guceceka nijwi ridahwanye
Kuruhu rwarushye, rwijimye cyangwa rwangiritse rwifoto rudafite ikibazo cyihariye cya pigment, antioxydeant ifasha cyane. Vitamine C ni ishingiro ryumvikana, kandi glutathione irashobora gutanga inyungu za antioxydeant. Ibiteganijwe bigomba gutegurwa nka 'gushya, ndetse ndetse nuruhu ', ntabwo ari urumuri rworoshye.
Indwara ya hyperpigmentation nyuma yo gutwikwa (PIH)
Ibimenyetso bisigaye nyuma ya acne cyangwa kurakara mubisanzwe bigenda bishira igihe, kurinda izuba no kwitonda byoroheje. Niba inshinge zikoreshwa, protocole nkeya hamwe na vitamine C cyangwa TXA birumvikana, kuko kuvura bikabije bishobora gutera pigment nshya. Incamake yacu uruhu rumurika inshinge za hyperpigmentation zisobanura ubwoko bwibanze bwa pigment muburyo burambuye.
Inkunga ya Antioxydeant hafi yubundi buryo
Vitamine C na glutathione bikunze gutoranywa nkibikoresho bifasha hafi ya laseri cyangwa ibishishwa. Ntabwo basimbuza gahunda yihariye yo kuvura.
Inzira yo guhuza: Impamvu amavuriro menshi akoresha yose uko ari atatu
Kuberako ibintu bitatu bikora ku ntambwe zitandukanye zo gushinga pigment, formula zigezweho zo kumurika akenshi zihuza TXA, vitamine C na glutathione aho guhitamo imwe. Amakuru yubuvuzi ashyigikira iyi logique, byibuze mubigeragezo bito. Mu igeragezwa-rihumye, rigabanijwe-mu maso y’abarwayi 24 ba melasma, TXA wongeyeho aside ya ascorbic yagabanije amanota MASI arenze TXA wongeyeho umwanya wa 8 na 12, nubwo ububabare bwaka bwagaragaye cyane kuruhande (Pazyar et al., 2022). Mu kindi kigeragezo cyo gutandukanya abarwayi 30, cocktail ya TXA 4 mg / mL, vitamine C 3% na glutathione 2% yagabanije mMASI kurenza TXA na vitamine C yonyine, hamwe n’ibipimo bisa n’umutuku, kubyimba no gukomeretsa (Iraji et al., 2019).
IV glutathione ntabwo ari imiti yemewe yo kwera uruhu kumasoko menshi. Mu nama ngishwanama ya 2019, Philippine FDA yavuze ko itigeze yemera ibicuruzwa byatewe inshinge kugira ngo byorohereze uruhu, byemera glutathione yatewe inshinge gusa nk'umugereka wa chimiotherapie ya cisplatine, anaburira ko hashobora kubaho umwijima, impyiko na nervice-sisitemu ndetse na syndrome ya Stevens-Johnson.
Vitamine C ikabije ya IV itwara ingaruka zayo. Iyi nama nyene yavuze ko inshinge za vitamine C zishobora gukora amabuye y'impyiko kandi ko dosiye nini yatumye hémodialyse ku bantu bafite ikibazo cya G6PD.
AOMA ikora ibisubizo byiza bya mesotherapi, harimo TXA, vitamine C hamwe na formulaire yo guhuza, kubitangwa na OEM. Urashobora gushakisha Urupapuro rwa AOMA rwera . MOQ itangirira kubice 200 kububiko na OEM byateganijwe. Gutumiza ibicuruzwa byoherejwe mugihe cyamasaha 24, kandi OEM iyobora ni ibyumweru 2-3 nyuma yubuhanzi, formulaire hamwe nibipfunyika byemejwe. AOMA ifite ibyemezo bya CE, ISO 13485, GMP na FDA.
Ibibazo
Nuwuhe muti mwiza wera?
Nta watsinze umwe. Kuri melasma, aside tranexamic ifite amakuru menshi yo gutera inshinge. Kubusa muri rusange, vitamine C ni amahitamo meza ya antioxydeant. Glutathione ahanini ni inyongera. Umwitozo agomba gusuzuma ikibazo cya pigment mbere yo guhitamo.
Glutathione iruta vitamine C yo kumurika uruhu?
Ntabwo bigaragara. Byombi bifite ibimenyetso byoroheje, byigihe gito. Vitamine C ifite amakuru menshi yo gutera inshinge za melasma, mugihe IV glutathione yananiwe gutsinda umwanya wawo mu igeragezwa ryayo ryonyine.
Acide tranexamic, vitamine C na glutathione birashobora guterwa hamwe?
Nibyo, cocktail ikomatanya irasanzwe, kandi ibigeragezo bito bitandukanijwe-byagaragaye ko kongeramo vitamine C, hanyuma glutathione, kuri TXA byongereye amanota ya melasma. Gutwika cyangwa gukomeretsa birashobora kwiyongera hamwe.
Ese inshinge zera zihindura burundu ibara ryuruhu?
Oya. Zishobora kuzimya pigment irenze ndetse no hanze, ariko ntizihindura ibara ryuruhu rusanzwe, kandi ibisubizo birashira bitarinze izuba no kubibungabunga.
IV glutathione ifite umutekano mukwera uruhu?
Abagenzuzi nka FDA yo muri Filipine baraburira kubirwanya, kandi isuzuma ryakozwe mu 2024 ryasuzumye IV glutathione yandujwe no kumurika uruhu kubera kutagira ingaruka n'ingaruka mbi.
Reba
Lee JH, Parike JG, Lim SH, n'abandi. Microinjection yimbere yimbere ya acide tranexamic yo kuvura melasma kubarwayi bo muri Aziya: ibizamini byambere byubuvuzi. Dermatol Surg . 2006; 32 (5): 626–631. PMID: 16706756.
Liao X, Cheng F, Jiang Y. Ingaruka n'umutekano bya mesotherapi hamwe na acide tranexamic na vitamine C mukuvura melasma: gusesengura meta no gusuzuma sisitemu. J Cosmet Dermatol . 2024; 23 (9): 2785–2792. PMID: 38693699.
Pazyar N, Molavi SN, Hosseinpour P, n'abandi. Ingaruka zo gutera inshinge za acide tranexamic na acide acorbike na acide tranexamic na placebo mukuvura melasma: ikigeragezo cyo kugereranya mumaso. Ubuzima Sci Rep . 2022; 5 (2): e537. PMID: 35284654.
Iraji F, Nasimi M, Asiliyani A, n'abandi. Ingaruka za mesotherapi hamwe na acide tranexamic na acide ya ascorbic hamwe na glutathione no kuvura melasma: igeragezwa ryo mumaso igereranije. J Cosmet Dermatol . 2019; 18 (5): 1416–1421. PMID: 30735611.
Zubair S, Hafeez S, Mujtaba G. Ingaruka za glutathione yimitsi na placebo yo kumurika uruhu. J Pak Assoc Dermatol . 2016; 26 (3): 177. https://jpad.com.pk/index.php/jpad/article/view/18
Telang PS. Vitamine C muri dermatology. Umuhinde Dermatol Kumurongo J. 2013; 4 (2): 143–146. PMID: 23741676.
Ubuyobozi bushinzwe ibiryo n'ibiyobyabwenge muri Philippines. Ubujyanama bwa FDA No 2019-182: Gukoresha nabi glutathione nkibikoresho byorohereza uruhu. 2019.
Iyi ngingo igamije uburezi gusa kandi ntabwo ari inama zubuvuzi. Imiti itera inshinge igomba gusuzumwa no gukorwa nababimenyereye babishoboye bakurikije amabwiriza yaho.
Dr. Emily Carter (MD, Mugenzi w’ishuri rikuru ry’Abanyamerika ryita ku ndwara z’ubuvuzi) ni umuganga w’ubuvuzi w’amavuta wo kwisiga yemewe mu mujyi wa New York ufite uburambe bw’imyaka irenga 9 mu kuzuza aside hyaluronike, kuvura inkovu, ndetse no mu maso hakeye cyane. Azwi cyane cyane kubuhanga afite mubuvuzi buhanitse bwo kuvura inshinge zorohereza neza inkovu za acne, zigatera gukira uruhu, kandi zigarura ubworoherane binyuze mu gutera inshinge zigamije gusana uruhu hamwe nubuhanga bwo kuzamura uruhu.
