Acide Tranexamic ni intungamubiri ikomoka kuri aside amine aside. Yakozwe bwa mbere nk'umuti wa antifibrinolytike, bivuze ko igabanya kuva amaraso mu guhagarika ihinduka rya plasminogene na plasmin. Abashakashatsi ba Dermatologue barabyishimiye nyuma yuko abashakashatsi babonye ko guhagarika inzira ya plasminogen - plasmin nabyo byagabanije pigmentation ya ultraviolet.
Mubuvuzi bwiza, TXA ubu ikoreshwa muburyo butatu:
Serumu yibanze hamwe na cream, mubisanzwe byibuze
Ibinini byo mu kanwa , byashyizweho n'abaganga kuri melasma irwanya
Indwara ya Melasma ikunze kwerekana imiyoboro mito mito kuruta uruhu ruzengurutse, kandi ibintu bikura mu mitsi bigaragara ko bigaburira ukwezi. Kuberako TXA nayo ikora kumuhanda wa plasmin igira uruhare muri angiogenez, irashobora gufasha muburyo butukura-umukara, imitsi isa na melasma. Ninimpamvu imwe TXA yitwara itandukanye na tyrosinase inhibitor.
Impamvu ibi bifite akamaro ko guhitamo imiti
Ibigize nka glutathione, vitamine C, aside kojic na arbutine ahanini bikora kuri synthesis ya melanin ubwayo. TXA ikora hejuru, kubimenyetso bibitera. Ibyo bituma uba umufatanyabikorwa wumvikana aho gusimburwa. Niba ushaka ibisobanuro kuruhande rwa antioxydeant, ingingo yacu kuri glutathione ninshinge zo kwera uruhu zisobanura uburyo glutathione igira ingaruka kuri pigment. Ibisigaye byiki gitabo bigumana na TXA na melasma.
Ibyo ibimenyetso bya Clinical byerekana
Microinjection ya TXA yizwe mubigeragezo byasuzumwe, nubwo ibyinshi ari bito kandi bifunguye-label. Ubushakashatsi bubiri bwakunze kuvugwa butanga ishusho ifatika:
Lee n'abandi, Kubaga Dermatologic (2006). Mu byumweru 12 byafunguye ubushakashatsi bwakozwe ku bagore 100 b’Abanyakoreya barwaye melasma, 0,05 mL ya TXA (4 mg / mL) batewe mu nda hagati ya cm 1 intera rimwe mu cyumweru. Abarwayi mirongo inani na batanu barangije ubushakashatsi. Ikigereranyo cya Melasma hamwe n’uburemere (MASI) byagabanutse kuva 13.22 kuri baseline kugera kuri 7.57 mu cyumweru cya 12, kandi ingaruka zavuzwe ko ari nto.
Budamakuntla n'abandi, Ikinyamakuru cyo kubaga Cutaneous na Aesthetic (2013). Abarwayi mirongo itandatu batoranijwe kuri microinjection ya TXA cyangwa TXA yatanzwe na microneedling, hamwe namasomo atatu ya buri kwezi. MASI yazamutseho 35,72% mu itsinda rya microinjection na 44.41% mu itsinda rya microneedling, nta bintu bikomeye byavuzwe.
Dr. Emily Carter (MD, Mugenzi w’ishuri rikuru ry’Abanyamerika ryita ku ndwara z’ubuvuzi) ni umuganga w’ubuvuzi w’amavuta wo kwisiga yemewe mu mujyi wa New York ufite uburambe bw’imyaka irenga 9 mu kuzuza aside hyaluronike, kuvura inkovu, ndetse no mu maso hakeye cyane. Azwi cyane cyane kubuhanga afite mubuvuzi buhanitse bwo kuvura inshinge zorohereza neza inkovu za acne, zigatera gukira uruhu, kandi zigarura ubworoherane binyuze mu gutera inshinge zigamije gusana uruhu hamwe nubuhanga bwo kuzamura uruhu.
