Research shows that cross-linked hyaluronic acid (HA), calcium hydroxyapatite (CaHA), and poly-L-lactic acid (PLLA) will respectively dominate the three major sub-sectors of precise filling, collagen stimulation, and global rejuvenation. AI is reconfiguring product development and marketing strategies through data insights.
Market Status Quo: The three major materials have formed differentiated technical routes
Hyaluronic acid : The king of technological depth and precise application
Cross-linked hyaluronic acid filler continues to maintain the largest Market share, with an expected 62% (Global Market Insights 2024). Its advantages lie in the immediate effect and reversibility, and it is suitable for shaping fine parts.
Single-phase cross-linked multi-density technology has become mainstream, enabling a single injection effect from deep support to shallow smoothness. It greatly simplifies the operation process for doctors and enhances the satisfaction of those seeking beauty.
Calcium hydroxyapatite (CaHA) : A key force in biological stimulation and contour remodeling
CaHA has been proven to have dual effects. "Biological stimulation" has become the core selling point of CaHA. Its value in stimulating the regeneration of autologous collagen is widely applied in areas such as facial and neck lifting, and even hand rejuvenation.
The effect provided by CaHA is progressive, and its duration usually lasts for 12 to 18 months, making it highly favored by mature customer groups.
Poly-l-lactic acid (PLLA) : A strategic weapon for all-round rejuvenation
The annual growth rate of demand for poly-L-lactic acid reached 28% (Transparency Market Research). Market education is becoming increasingly mature, and both doctors and consumers have recognized its huge potential as a "cell-level" regenerative material.
PLLA is aimed at fundamentally improving the loss of organizational capacity, and its effect can last for more than 25 months, which is highly attractive to high-net-worth clients seeking fundamental solutions.
Product Showdown - Scientifically Building the Best Solutions for Your Customers
How to select the most suitable materials for different indications and customer groups? The following table provides you with a clear strategic map.
| Parameters |
HA |
CaHA |
PLLA |
| Mechanism of action |
Physical filling + moisturizing |
Filling + collagen stimulation |
Collagen regeneration |
| Time to take effect |
Instant |
Immediate + 3-month enhancement |
1-3 months gradually |
| Maintenance cycle |
6 to 18 months |
12 to 18 months |
25 months and more |
| Applicable area effect |
Shape lips and nose bridge |
Mid-deep lift, skin quality improvement |
The entire department is rejuvenatin |
AOMA's product portfolio strictly adheres to this technical route:
2ML HA+LIDO compound water light, for instant fine engraving:
• Dual benefits: HA fills instantly, LIDO relieves pain.
• High-efficiency skin renewal: Targeting wrinkles and loose skin, it achieves a comprehensive improvement in skin quality.
• Convenient operation: Pre-mixed ratio formula simplifies the treatment process, and the effect is stable and expected.
2ML CaHA+ 0.3% LIDO for medium and long-term contour lifting and skin quality improvement, activating collagen regeneration:
• The particles are uniform and have good suspension properties.
• Instant filling and shaping provide stronger support and durability, making the shaping effect more natural, three-dimensional and less prone to displacement
1ML PLLA+HA is used for global rejuvenation, with the most natural and long-lasting effect, fundamentally improving skin quality:
• Golden ratio: Combining the regenerative capacity of PLLA with the immediate support effect of HA.
• Comprehensive rejuvenation: Suitable for improving facial wrinkles, loose contours and skin texture.
• High customer satisfaction: One treatment, double benefits, significantly enhancing customer stickiness.
AI Empowerment: From Market Data to Precise Decision-making
AI analysis has identified three key trends. Search volume for mid-face regeneration in the North American market has increased by 147%, indicating a rise in demand for CaHA and PLLA. The global attention to our composite solutions has increased by 152% year-on-year, verifying the market positioning of our PLLA+HA products. The demand for personalized customization has increased by 89%, which is in perfect alignment with our strategy of strengthening OEM capabilities.
These insights directly guide product development. For instance, the lip customization formula for the Asian market has passed clinical tests, and customer feedback satisfaction has increased by 34%.
Cooperation Model: Customized services based on supply chain advantages
We offer complete vertically integrated solutions. All products comply with the ISO 13485 quality standard and are equipped with multilingual instruction manuals. For different regional demands, customized adjustments of HA components are supported, including crosslinking degree, concentration and gel hardness. The packaging solutions range from 1ml single support to 50 clinic exclusive sets.
Dealers can receive support in three aspects:
• Regional strategy planning based on AI market data.
• The development of specialized formulas for specific parts.
• A complete set of marketing materials and training systems. This cooperation model has helped. European partners increase their market share by 19% within six months.
Conclusion
The market opportunities in 2025 belong to those pioneers who possess strategic vision, have a comprehensive product line and can empower decision-making with technology and data. By choosing AOMA, you are not merely selecting a medical aesthetics product supplier with a 23-year reputation, but also a strategic partner dedicated to growing together with you and creating a shared future.
We not only offer a wide range of products from innovative PLLA+HA composite products and bio-stimulated CaHA to comprehensive OEM/ODM solutions, but also help you win through cutting-edge market insights.
Act now and contact us to discuss customized cooperation: Do you wish to have an exclusive HA formula for specific areas (such as lips, nose) or specific skin types? Click to book an appointment with our OEM/ODM expert team to tailor a unique and personalized product solution for you.
FAQ
Q1: What are the main differences between Hyaluronic Acid fillers, CaHA fillers, and PLLA fillers?
HA fillers are gels of hyaluronic acid that provide immediate volume and hydration with variable longevity (typically 6–18 months). CaHA fillers use calcium hydroxylapatite microspheres in a carrier gel, offering immediate lift plus longer-term collagen stimulation (12–18 months). PLLA fillers use poly-L-lactic acid to stimulate collagen production gradually over several months, with results lasting about 18–24 months. Safety profiles are similar when administered by trained professionals, with product-specific contraindications.
Q2: Which filler is best for lip augmentation and facial contouring?
For lips, HA fillers are generally preferred due to their malleability, reversibility, and immediate results. For facial contouring (cheeks, jawline), HA can be ideal for precision, while CaHA may provide stronger lift in deeper planes. PLLA is less commonly used for primary contouring and is more suited for gradual collagen-driven improvements in mild to moderate volume loss.
Q3: How long do HA, CaHA, and PLLA fillers last?
Typical durations: HA fillers 6–18 months depending on product and area; CaHA fillers 12–18 months (some formulations up to 24 months in certain sites); PLLA fillers 18–24 months with gradual collagen buildup. Individual factors (age, metabolism, injection site) can vary results.
Q4: Which filler type is best for promoting collagen vs providing immediate volume?
HA fillers deliver immediate volume and hydration. CaHA offers both immediate lift and ongoing collagen stimulation due to biostimulatory properties. PLLA is primarily collagen-stimulating, producing gradual volume over months as collagen forms, with less immediate volumizing effect.
Q5: How do the injection techniques differ among HA, CaHA, and PLLA?
HA often uses superficial to deep injection planes with cannulas or needles for precise shaping. CaHA can be used in mid-to-deep dermal planes or subcutaneous layers to achieve lifting; some practitioners use dilutions for smoother integration. PLLA is typically reconstituted and injected in a deeper plane with a technique.
