You can expect semaglutide injection to help lower body fat a lot. Studies show semaglutide injection can cause about 15.7% weight loss. The table below shows how semaglutide injection works compared to other treatments:
Treatment | Weight Loss (%) | Lean Mass Change (%) | Fat Mass Contribution (%) |
Semaglutide 2.4mg | -15.7 | -7.4 | 71.8 |
Most of the weight you lose will be from fat. Your muscle mass will mostly stay the same. Some people may have mild stomach problems. But most people do fine with semaglutide injection.
Key Takeaways
Semaglutide injections can help you lose weight. You may lose about 15% to 20% of your body weight. Most of the weight you lose is fat. You will keep most of your muscle.
The treatment slows down how fast your stomach empties. It helps control your cravings. It helps your body use insulin better. This makes it easier for you to eat less.
Some people get mild stomach problems. These can be nausea or diarrhea. These side effects usually get better after some time.
For best results, use semaglutide with healthy eating. You should also exercise often. This helps you lose more weight and stay healthy.
Talk to your doctor before you start semaglutide. This is important if you have health problems. These include thyroid cancer or stomach issues.
Semaglutide Injection Overview
How It Works
You might ask how once-weekly semaglutide helps you lose fat. This medicine works in a few ways:
Once-weekly semaglutide makes your stomach empty slower. You stay full longer after eating.
It works with GLP-1 receptors in your body. These help your body make more insulin and burn more fat.
Once-weekly semaglutide helps your body use energy better. It helps you burn more energy and stops new fat from forming.
You may eat less because once-weekly semaglutide controls cravings. It helps you want fewer high-calorie foods.
The medicine also affects the Wnt/β-catenin pathway. This pathway helps stop new fat cells from forming.
Once-weekly semaglutide does more than help you lose weight. It can lower your blood sugar, improve cholesterol, and help your heart stay healthy.
Doctors use steps for once-weekly semaglutide dosing:
1. Start with a small dose for four weeks.
2. Raise the dose each week, depending on how you feel.
3. Reach your goal dose by week ten or later, based on your needs.
Appetite and Metabolism
Once-weekly semaglutide changes how you think about food. You will probably feel less hungry and have fewer cravings. In one study, people using once-weekly semaglutide ate much less food—about 3,036 kilojoules less each day—than people who did not use it. You may find it easier to skip snacks and big meals.
Your metabolism gets help from once-weekly semaglutide. Your resting metabolic rate may not change much, but the medicine helps your body use insulin better and lowers blood sugar after meals. Once-weekly semaglutide can also help your cholesterol and blood pressure, which is good for your heart and blood vessels.
Semaglutide's effects go beyond losing weight. You get better control of blood sugar, lower cholesterol, and a healthier heart. Once-weekly semaglutide is a strong way to manage your weight and improve your health.
Benefit of Once-Weekly Semaglutide | What You May Notice |
Appetite control | Less hunger, fewer cravings |
Blood sugar improvement | Lower blood sugar after meals |
Cholesterol and heart health | Better cholesterol, lower blood pressure |
Fat reduction | Most weight lost comes from fat, not muscle |
Clinical Evidence
You might want to know how well semaglutide helps with weight loss. Big studies show it works well for adults with obesity. In the STEP 1 trial, almost 2,000 people with obesity took part. The table below shows what happened:
Study | Participants | Average Weight Loss | Body Composition Improvement |
STEP 1 | 1,961 adults | ~15% | Less body fat and more lean body mass |
Semaglutide can help you lose a lot of weight. After 52 weeks, people lost about 15.6% of their weight. After 104 weeks, they lost about 15.2%. This means people kept the weight off for a long time. Most people with obesity saw big changes in their weight.
The STEP 1 trial also checked how many people hit important weight loss goals. The table below shows how many people lost weight with semaglutide and with a placebo:
Weight Loss Percentage | Semaglutide 2.4 mg | Placebo |
≥5% | 86% - 89% | 29% - 48% |
≥10% | 69% - 79% | 12% - 27% |
≥15% | 51% - 64% | 5% - 13% |
More than half of people using semaglutide lost at least 15% of their weight. Only a few people in the placebo group did this. These results show semaglutide works well for weight loss.
In the STEP 1 trial, about half of the people lost 15% or more of their weight. About one-third lost 20% or more. Semaglutide helps people lose more weight than just changing their lifestyle.
You can also see how fast people lose weight. The chart below shows average weight loss at different times:
In the first month, you might lose 2-4 pounds.
By three months, most people lose about 14.8 pounds (5.9%).
At six months, you could lose around 27.1 pounds (10.9%).
By 28 weeks, people lose about 12% of their starting weight.
These results show semaglutide helps you lose weight quickly and keep it off. The clinical trial data shows strong results.
Fat vs. Muscle
You may wonder if you lose fat or muscle. Studies show most weight loss comes from losing fat. In one study with 140 people with obesity, semaglutide helped lower extra body fat, even belly fat. The table below shows the results:
Study Type | Result Description | Participants |
Clinical Study | Semaglutide lowered extra body fat, including belly fat. | 140 |
Another study found semaglutide cut belly fat by 16% and waist size by 6% in 26 weeks. This means semaglutide targets the worst fat in your body.
Study Type | Result Description | Duration |
Randomized Controlled Trial | Semaglutide cut belly fat by 16% and waist by 6%. | 26 weeks |
You also want to keep your muscle when losing weight. Semaglutide helps with this. The table below compares fat loss and muscle loss for people who got semaglutide and those who got a placebo:
Group | Fat Mass Loss (%) | Lean Mass Loss (%) |
Semaglutide | 10.4 | 6.9 |
Placebo | 1.2 | 1.5 |
Most of the weight lost is fat, not muscle. Your body will look better. People with obesity who got semaglutide lost more fat than those who got a placebo. You can expect to keep most of your muscle while losing fat.
Doctors say some muscle loss happens with any weight loss plan. But semaglutide helps you keep more muscle than other treatments.
Semaglutide Treatment Safety
Common Side Effects
You might wonder if semaglutide treatment is safe. Most people notice mild side effects at first. Your body needs time to get used to it. The most common side effects happen in your stomach and digestion. You could feel sick or have changes when you go to the bathroom. Here is a table that shows the most reported side effects:
Side Effect | Prevalence (%) |
Nausea | ≥5% |
Vomiting | ≥5% |
Diarrhea | ≥5% |
Abdominal Pain | ≥5% |
Constipation | ≥5% |
These side effects are common with many obesity treatments. Most people feel better after some time. Drinking water and eating small meals can help you feel better. If you worry about safety, ask your healthcare provider.
Tip: If you feel sick after starting semaglutide treatment, eat bland foods and skip greasy meals. This can help your stomach feel better.
Comparison to Other Treatments
Lifestyle Changes
You can start losing weight by changing your habits. Eating healthy foods helps your body. Moving more each day is good for you. Many people try to eat less and exercise more. These steps work best if you keep doing them. Some people lose 5% to 10% of their weight this way. It can be hard to keep the weight off without help. For some, these changes are enough. Others need extra support to reach their goals.
Other Medications
There are different medicines for weight loss. Each medicine works in its own way. Some help you feel full faster. Others change how your body uses fat. The table below shows how much weight people lose with each medicine:
Medication | Average Weight Loss (%) |
Tirzepatide (Zepbound) | Up to 22.5% |
Semaglutide (Wegovy) | Up to 14.9% |
Liraglutide (Saxenda) | ~8% |
Phentermine-topiramate (Qsymia) | 7–11% |
Naltrexone-bupropion (Contrave) | ~5–9% |
Semaglutide helps many people lose more weight than other medicines. Tirzepatide helps people lose even more weight. Some medicines can cause more side effects. You should talk to your doctor to find the best choice for you.
Surgery
Bariatric surgery is another way to lose weight. This surgery is for people with severe obesity. Surgery can help you lose 20% to 35% of your weight. The table below compares surgery and GLP-1 medications:
Feature | GLP-1 Medications (e.g., Wegovy®, Zepbound™) | Bariatric Surgery (Gastric Sleeve, Gastric Bypass) |
Average Weight Loss – Real World | 5% total body weight (12 lbs in 2 years) | 24% total body weight (58 lbs in 2 years) |
Average Weight Loss – Clinical Trials | 15–21% with consistent, long-term use | 20–35% on average; some patients lose 50% or more |
Common Side Effects / Risks | Nausea, diarrhea, constipation, fatigue | Surgical risks (bleeding, infection, leaks), vitamin/mineral deficiencies |
Surgery helps people lose the most weight. But surgery has more risks than medicine. You may need to take vitamins forever after surgery. Semaglutide and other GLP-1 medicines are less invasive ways to help you lose weight.
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Conclusion
Semaglutide injection can help you lose a lot of body fat. Most people lose between 15% and 20% of their weight. You will lose fat but keep most of your muscle. The table below shows key facts:
Key Takeaways | Details |
Positive Impact | Most lose 15–20% of their weight. One-third lose about 10%. |
Challenges | You must use it for life. Some get nausea as a side effect. |
Financial Barriers | It costs about $1,200 each month. |
Before you start semaglutide, talk to your doctor about these things:
Eating healthy foods and exercising
Making goals you can reach for weight loss
If you have thyroid cancer, diabetic eye problems, or MEN syndrome
Semaglutide is best for adults with obesity who want long-term results and are ready to make healthy changes.
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OTESALY® Mesotherapy Solution OTESALY Fat Dissolving solution and OTESALY Fat-X solution are the perfect set for weight loss. According to clinical test, normally it can lose 3-10 pounds in 1 week.
Fat-X solution is to slim the whole body, and the fat dissolving solution is to reduce fat locally. You can use fat dissolving solution first, after 7-10 days, use Fat-X solution. The weight loss effect will be much better.
FAQ
Q1: How fast will I see results with semaglutide injection?
A1: You may notice weight loss within the first month. Most people see steady progress each week. By three months, you could lose about 5% to 10% of your starting weight.
Q2: Can I stop semaglutide after reaching my goal weight?
A2: If you stop semaglutide, you may regain weight. Doctors recommend you continue treatment to keep results. Always talk to your healthcare provider before making changes.
Q3: Will semaglutide help me lose belly fat?
A3: Yes, semaglutide targets body fat, including belly fat. Studies show you can lose up to 16% of belly fat in six months. You will also see a smaller waist size.
Q4: Do I need to change my diet while using semaglutide?
A4: You get the best results when you eat healthy foods and stay active. Semaglutide works better with a balanced diet. Try to eat more vegetables, lean protein, and whole grains.
Q5: Is semaglutide safe for everyone?
A5: Semaglutide is not safe for everyone. You should not use it if you have certain health problems, like thyroid cancer or MEN 2. Always check with your doctor before starting treatment.
