Melasma ndi imodzi mwazovuta kwambiri zomwe zipatala za pigment zimachiza. Imabwerera pambuyo pa laser, imayaka ndi dzuwa ndi mahomoni, ndipo nthawi zambiri imalephera kuyankha ku hydroquinone yokha. Ichi ndichifukwa chake jakisoni wa tranexamic acid woyeretsa khungu ndi kuwongolera melasma wachoka panjira yodziwika bwino kupita ku pempho lokhazikika muzokongoletsa ku Asia, Middle East ndi Europe. Bukuli likufotokoza za momwe tranexamic acid (TXA) imagwirira ntchito pa pigment, zomwe zidziwitso zachipatala zomwe zasindikizidwa zimawonetsa, momwe madokotala nthawi zambiri amayendetsera TXA mesotherapy protocol, ndi zomwe ogawa ndi mtundu wachipatala ayenera kuyang'ana asanapeze fomula ya TXA.
Melasma si ' melanin wochuluka kwambiri '. Zimaphatikizapo kukambirana pakati pa mitundu ingapo ya maselo pakhungu. Nayi mtundu wosavuta wa momwe TXA imasokoneza.
Kuletsa chizindikiro cha plasmin
Khungu likakhala ndi kuwala kwa UV, keratinocyte imapanga plasminogen activator yambiri. Plasmin kenako imatulutsa mamolekyu ozindikiritsa monga arachidonic acid ndi prostaglandins, omwe amakankhira ma melanocyte kuti apange melanin yambiri. TXA imaletsa kuyambitsa kwa plasminogen, kuti chizindikiro cholimbikitsa chifooke poyambira.
Kulunjika gawo la mitsempha
Zotupa za melasma nthawi zambiri zimawonetsa mitsempha yaying'ono yamagazi kuposa khungu lozungulira, ndipo kukula kwa mitsempha kumawoneka kuti kumadyetsa mtundu wa pigment. Chifukwa TXA imagwiranso ntchito pa njira ya plasmin yomwe imakhudzidwa ndi angiogenesis, ingathandize ndi mawonekedwe ofiira-bulauni, a mitsempha ya mitsempha ya melasma. Ichi ndi chifukwa chimodzi chomwe TXA imachita mosiyana ndi ma inhibitors oyera a tyrosinase.
Lee et al., Opaleshoni ya Dermatologic (2006). Mu kafukufuku wotseguka wa masabata 12 wa amayi 100 aku Korea omwe ali ndi melasma, 0.05 mL ya TXA (4 mg/mL) anabayidwa intradermally pa 1 cm intervals kamodzi pa sabata. Odwala makumi asanu ndi atatu mphambu asanu anamaliza phunzirolo. Mlingo wa Melasma Area ndi Severity Index (MASI) unagwa kuchokera ku 13.22 poyambira mpaka 7.57 pa sabata 12, ndipo zotsatira zake zinafotokozedwa ngati zochepa.
Budamakuntla et al., Journal of Cutaneous and Aesthetic Surgery (2013). Odwala makumi asanu ndi limodzi adasinthidwa kukhala TXA microinjection kapena TXA yoperekedwa ndi microneedling, ndi magawo atatu pamwezi. MASI yakula ndi 35.72% mu gulu la microinjection ndi 44.41% mu gulu la microneedling, popanda zovuta zazikulu zomwe zanenedwa.
Zomwe maphunziro awa akuwonetsa:
TXA mesotherapy imatha kuchepetsa kuopsa kwa melasma pakadutsa milungu 8-12.
Zotsatira zimasiyana. Mu kafukufuku wa Lee, odwala ambiri adawona kusintha kwawo kukhala 'mwachilungamo' (26-50% kuunika) m'malo mololedwa kwathunthu.
Njira yobweretsera ndiyofunika, ndipo kuphatikiza ndi microneedling kungapangitse kulowa.
Kutalikirana ndi voliyumu: ma aliquot ang'onoang'ono amafalikira mofanana pachilondacho. Ma protocol osindikizidwa omwe amagwiritsidwa ntchito pafupifupi 0.05 mL pa mfundo pa 1 cm intervals.
Zida zobweretsera: syringe ya insulin, mfuti ya meso, kapena cholembera cha microneedling ndi roller, kutengera kapangidwe kazinthu komanso zokonda zachipatala.
Nthawi zambiri
Maphunziro osindikizidwa omwe amagwiritsidwa ntchito mlungu uliwonse (Lee 2006) kapena magawo a mwezi uliwonse (Budamakuntla 2013). Mayankho ambiri amalonda a TXA mesotherapy amalimbikitsa gawo limodzi pakatha milungu iwiri iliyonse. Maphunzirowa nthawi zambiri amakhala ndi magawo 4-8, ndikutsatiridwa ndi chithandizo chamankhwala ngati pakufunika.
Sourcing TXA Mesotherapy Solutions: Mndandanda wa Ogawa ndi Mitundu Yachipatala
Kufuna kwa zinthu za TXA ndikwamphamvu m'misika yokhala ndi melasma yambiri, kuphatikiza Southeast Asia, Middle East, Latin America ndi madera ena aku Europe. Ngati mukufuna kuitanitsa kapena kulembera mwachinsinsi fomula ya TXA, onani:
Amakwaniritsa zolinga zosiyanasiyana. Oral TXA ndi mankhwala omwe amalembedwa ndi dokotala ndipo amafunikira kuyang'aniridwa ndi dokotala. Intradermal TXA imapereka mlingo waung'ono wamba mwachindunji ku zilondazo. Dermatologist angaphatikize zonse ziwiri pamilandu yosamva.
Kodi melasma ingabwerere pambuyo pa chithandizo cha TXA?
Inde. Melasma ndi yosatha ndipo imayambitsidwa ndi kuwala kwa UV, kutentha ndi mahomoni. Kutetezedwa kwa dzuwa tsiku ndi tsiku komanso magawo okonzekera nthawi ndi nthawi ndikofunikira kuti musunge zotsatira.
Kodi TXA ingaphatikizidwe ndi laser kapena peels?
Madokotala ambiri amagwiritsa ntchito TXA pamodzi ndi ma peels ofatsa kapena ma laser otsika mphamvu. Kuchiza kuyenera kugawidwa moyenerera ndikulinganizidwa ndi katswiri wodziwa bwino kuti apewe kupsa mtima ndi kubwereza mtundu wa pigment.
Maumboni: Lee JH, Park JG, Lim SH, et al. Localized intradermal microinjection ya tranexamic acid yochizira melasma mwa odwala aku Asia: kuyesa koyambirira kwachipatala. Dermatol Surg. 2006; 32 (5): 626-631. Budamakuntla L, Loganathan E, Suresh DH, et al. Kufufuza kosasinthika, kotseguka, kuyerekezera kwa tranexamic acid microinjections ndi tranexamic acid yokhala ndi microneedling kwa odwala melasma. J Cutan Aesthet Surg. 2013;6(3):139–143.
Nkhaniyi ndi yongodziwitsa akatswiri okha komanso si malangizo azachipatala. Chithandizo chiyenera kuchitidwa ndi odziwa bwino ntchito mogwirizana ndi malamulo a m'deralo.
Dr. Emily Carter (MD, Fellow of the American Academy of Dermatology) ndi dotolo wodziwika bwino wodzikongoletsa ku New York City ndipo ali ndi zaka zopitirira 9 akudziwa mwapadera za hyaluronic acid fillers, kuchiza ziphuphu zakumaso, komanso kuyang'ana pang'ono kumaso. Amadziwika makamaka chifukwa cha ukatswiri wake pamankhwala apamwamba obaya jekeseni omwe amachepetsa zipsera za ziphuphu zakumaso, kulimbikitsa machiritso a khungu, ndikubwezeretsa kusalala kudzera mu jakisoni wokonzanso khungu ndi njira zolimbikitsira khungu.
